重庆医学
重慶醫學
중경의학
CHONGQING MEDICAL JOURNAL
2013年
27期
3231-3233
,共3页
王琨%高惠峰%孟志强%陈震%林钧华%王鹏%冯兰云%沈晔华%陈联誉%石卫东%刘鲁明
王琨%高惠峰%孟誌彊%陳震%林鈞華%王鵬%馮蘭雲%瀋曄華%陳聯譽%石衛東%劉魯明
왕곤%고혜봉%맹지강%진진%림균화%왕붕%풍란운%침엽화%진련예%석위동%류로명
超声学%中草药%胰腺肿瘤
超聲學%中草藥%胰腺腫瘤
초성학%중초약%이선종류
Ultrasonics%drugs,Chinese herbal%pancreatic neoplasms
目的探讨清热化湿中药联合高强度聚焦超声（HIFU ）治疗晚期胰腺癌的临床疗效。方法86例晚期胰腺癌患者中有18例进行了2～3次HIFU治疗，其余68例仅接受了1次HIFU治疗，伴肝转移的53例患者中有8例同时进行了肝转移灶的HIFU消融治疗。患者HIFU治疗前后和随访期间均给予清热化湿为主的中药治疗。结果治疗后1个月HIFU辐照病灶完全缓解（CR）0例，部分缓解（PR）8例（9．3％），稳定（SD）64例（74．4％），进展（PD）14例（16．3％）。全组患者中位生存时间6个月，半年和1年生存率分别是52．0％、11．4％。73例治疗前糖类抗原199（CA199）升高的患者，治疗后有12例下降，36例治疗前糖类抗原242（CA242）升高的患者治疗后有15例下降。所有病例治疗后疼痛缓解有效率为70．9％（61/86）。结论清热化湿中药联合HIFU治疗是晚期胰腺癌有效的治疗方法。
目的探討清熱化濕中藥聯閤高彊度聚焦超聲（HIFU ）治療晚期胰腺癌的臨床療效。方法86例晚期胰腺癌患者中有18例進行瞭2～3次HIFU治療，其餘68例僅接受瞭1次HIFU治療，伴肝轉移的53例患者中有8例同時進行瞭肝轉移竈的HIFU消融治療。患者HIFU治療前後和隨訪期間均給予清熱化濕為主的中藥治療。結果治療後1箇月HIFU輻照病竈完全緩解（CR）0例，部分緩解（PR）8例（9．3％），穩定（SD）64例（74．4％），進展（PD）14例（16．3％）。全組患者中位生存時間6箇月，半年和1年生存率分彆是52．0％、11．4％。73例治療前糖類抗原199（CA199）升高的患者，治療後有12例下降，36例治療前糖類抗原242（CA242）升高的患者治療後有15例下降。所有病例治療後疼痛緩解有效率為70．9％（61/86）。結論清熱化濕中藥聯閤HIFU治療是晚期胰腺癌有效的治療方法。
목적탐토청열화습중약연합고강도취초초성（HIFU ）치료만기이선암적림상료효。방법86례만기이선암환자중유18례진행료2～3차HIFU치료，기여68례부접수료1차HIFU치료，반간전이적53례환자중유8례동시진행료간전이조적HIFU소융치료。환자HIFU치료전후화수방기간균급여청열화습위주적중약치료。결과치료후1개월HIFU복조병조완전완해（CR）0례，부분완해（PR）8례（9．3％），은정（SD）64례（74．4％），진전（PD）14례（16．3％）。전조환자중위생존시간6개월，반년화1년생존솔분별시52．0％、11．4％。73례치료전당류항원199（CA199）승고적환자，치료후유12례하강，36례치료전당류항원242（CA242）승고적환자치료후유15례하강。소유병례치료후동통완해유효솔위70．9％（61/86）。결론청열화습중약연합HIFU치료시만기이선암유효적치료방법。
Objective To evaluate the clinical efficacy of Qingrehuashi herbal formula combined with high intensity focused ul-trasound(HIFU ) in the treatment of advanced pancreatic cancer .Methods 86 patients with pancreatic cancer (22 case of III stage and 64 case of IV stage) were included in this study .18 cases were performed the HIFU therapy for 2-3 times .Other 68 cases re-ceived once HIFU therapy ,among 53 cases of liver metastasis ,8 cases were simultaneously conducted HIFU ablation therapy on liv-er metastasis .The patients were given Chinese medicines dominated by Qingrehuashi before and after HIFU therapy and during fol-low up period .Results The single evaluation on HIFU irradiation cases after 1 month:complete remision(CR) in 0 case ,partial re-mission(PR) in 8 cases(9 .3% ) ,stable disease(SD in 64 cases(74 .4% ) and progress disease(PD) in 14 cases(16 .3% ) .The median survival rate of 1 year and half a year was 52 .0% and 11 .4% .Among 73 cases of increased CA199 before treatment ,CA199 after treatment was decreased in 12 cases .Among 36 cases of increased CA242 before treatment ,CA242 after treatment was decreased in 15 cases .The effective rate of analgesic relief in all the cases was 70 .9% (62/86) .Conclusion The integrated therapy of Qingre-huashi herbal formula and HIFU is an effective method for treating advanced pancreatic cancer .
