CAJ | 학술논문

目的探讨中国苏南地区汉族人群血清C-反应蛋白（CRP）水平、CRP基因C＋1444T多态性与急性心肌梗死（AMI）的相关性。方法采用聚合酶链反应-限制性片段长度多态性技术检测了227例A M I患者（A M I组）和161例非冠心病者（对照组）的CRP基因C＋1444T多态性，并应用酶联免疫吸附试验测定血清CRP水平。结果 AMI组CRP基因C＋1444T型分布频率为CC 82．38％、CT 17．62％、T T 0％；对照组分别为CC 86．96％、CT 13．04％、T T 0％，两组基因型分布频率之间差异无统计学意义（P＞0．05）。AMI组血清CRP水平显著高于对照组，差异有统计学意义（P＜0．01）。不同基因型之间的血清CRP水平比较差异均无统计学意义（P＞0．05）。结论中国苏南地区汉族人群的CRP基因C＋1444T多态性不增加AMI的易感性，并且不影响其血清CRP水平。
목적탐토중국소남지구한족인군혈청C-반응단백（CRP）수평、CRP기인C＋1444T다태성여급성심기경사（AMI）적상관성。방법채용취합매련반응-한제성편단장도다태성기술검측료227례A M I환자（A M I조）화161례비관심병자（대조조）적CRP기인C＋1444T다태성，병응용매련면역흡부시험측정혈청CRP수평。결과 AMI조CRP기인C＋1444T형분포빈솔위CC 82．38％、CT 17．62％、T T 0％；대조조분별위CC 86．96％、CT 13．04％、T T 0％，량조기인형분포빈솔지간차이무통계학의의（P＞0．05）。AMI조혈청CRP수평현저고우대조조，차이유통계학의의（P＜0．01）。불동기인형지간적혈청CRP수평비교차이균무통계학의의（P＞0．05）。결론중국소남지구한족인군적CRP기인C＋1444T다태성불증가AMI적역감성，병차불영향기혈청CRP수평。
Objective To investigate the relationship between serum C-reactive protein(CRP) level ,CRP gene C+1444T poly-morphism and the risk with Acute myocardial infarction (AMI) in Chinese Han population in Sunan region .Methods The CRP gene C+1444T polymorphism was genotyped by Polymerase reaction restriction-fragment length polymorphism (PCR-RFLP) and the serum CRP level was measured by enzyme linked immunosorbent assay (ELISA) between 227 patients with AMI(AMI group) and 161 control subjects .Results No differences were found in genotype distribution between AMI group and controls (CC 82 .38% ,CT 17 .62% ,TT 0% vs 86 .96% ,13 .04% ,0% )(P>0 .05) .The serum CRP level in AMI group was significantly higher than controls(P< 0 .01) .There was no differences in the serum level between any genotypes of the CRP gene C + 1444T (P<0 .05) .Conclusion The CRP gene C+1444T polymorphism is not associate with increased risk of AMI ,and it have no effect with the serum level in Chinese Han population in Sunan region .