CAJ | 학술논문

目的：探讨室内质控数据和室间质评回报结果在临床凝血项目测量不确定度评定中的应用。方法参照中国合格评定国家认可委员会（CNAS）“自上而下”的方法，收集襄阳市中心医院医学检验部6个月的室内质控数据和2012～2013年3次卫生部临床检验中心室间质评结果，评定凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）、血浆纤维蛋白原浓度（Fbg）的测量不确定度。结果 PT在12．7s和21．0s时的扩展不确定度分别为1．1s和2．0s，APTT在36．6s和50．6s时的扩展不确定度为2．6s和5．3s，Fbg在3．32g/L时的扩展不确定度为0．30g/L。结论利用室内质控数据和室间质评回报结果，对常规凝血检测指标测量不确定度进行评定，是经济实用和可接受的方法，具有一定的临床应用价值。
목적：탐토실내질공수거화실간질평회보결과재림상응혈항목측량불학정도평정중적응용。방법삼조중국합격평정국가인가위원회（CNAS）“자상이하”적방법，수집양양시중심의원의학검험부6개월적실내질공수거화2012～2013년3차위생부림상검험중심실간질평결과，평정응혈매원시간（PT）、활화부분응혈활매시간（APTT）、혈장섬유단백원농도（Fbg）적측량불학정도。결과 PT재12．7s화21．0s시적확전불학정도분별위1．1s화2．0s，APTT재36．6s화50．6s시적확전불학정도위2．6s화5．3s，Fbg재3．32g/L시적확전불학정도위0．30g/L。결론이용실내질공수거화실간질평회보결과，대상규응혈검측지표측량불학정도진행평정，시경제실용화가접수적방법，구유일정적림상응용개치。
Objective To explore the application of evaluation of measurement uncertainty in routine coagulation assays based on the data of internal quality control (IQC) and results of external quality assessment (EQA) .Methods Data of clinical coagulation assays of clinical laboratory of Xiangyang city hospital were collected ,Which came from six months of IQC and 3 times of EQA of ministry of health clinical laboratory center from 2012 to 2013 .The combined and expanded uncertainties of 3 measurements(PT , APTT and Fbg) were evaluated according to CNAS "top-down"approach .Results When PT were in 12 .72 s and 21 .04 s ,its ex-panded uncertainty were 1 .06 s and 1 .96 s ,and APTT in 36 .6 s and 50 .6 s were 2 .59 s and 5 .30 s ,and Fbg in 3 .32 g/L was 0 .30 g/L .Conclusion Evaluation of measurement uncertainty by using internal quality control data and EQA results for routine coagula-tion detection index is economical and practical and acceptable way ,with good clinical practice .