中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2014年
23期
1-2
,共2页
乳腺肿瘤%乳房切除术,改良根治性%氟尿嘧啶%间质化疗
乳腺腫瘤%乳房切除術,改良根治性%氟尿嘧啶%間質化療
유선종류%유방절제술,개량근치성%불뇨밀정%간질화료
Breast neoplasms%Mastectomy,modified radical%Fluorouracil%Interstitial chemotherapy
目的 探讨乳腺癌术中放置氟尿嘧啶植入剂间质化疗的临床意义.方法 60例行乳腺癌改良根治术患者按术中是否使用氟尿嘧啶植入剂分为治疗组(40例)和对照组(20例).对照组常规手术治疗,治疗组在常规手术后,蒸馏水冲洗创面,分别在肿瘤区域下方、胸大小肌间、腋窝血管下0.5 cm均匀放置氟尿嘧啶植入剂(剂量0.4 g).观察两组术后骨髓抑制、肝肾功能、胃肠道反应、皮瓣坏死、皮下积液、局部复发等情况.结果 两组骨髓抑制、肝肾功能异常、皮瓣坏死、皮下积液及胃肠道反应发生率比较差异无统计学意义(P＞0.05).治疗组局部复发率低于对照组[0比20.0％(4/20)],差异有统计学意义(P＜0.05).结论 乳腺癌改良根治术中应用氟尿嘧啶植入剂是安全有效的.
目的 探討乳腺癌術中放置氟尿嘧啶植入劑間質化療的臨床意義.方法 60例行乳腺癌改良根治術患者按術中是否使用氟尿嘧啶植入劑分為治療組(40例)和對照組(20例).對照組常規手術治療,治療組在常規手術後,蒸餾水遲洗創麵,分彆在腫瘤區域下方、胸大小肌間、腋窩血管下0.5 cm均勻放置氟尿嘧啶植入劑(劑量0.4 g).觀察兩組術後骨髓抑製、肝腎功能、胃腸道反應、皮瓣壞死、皮下積液、跼部複髮等情況.結果 兩組骨髓抑製、肝腎功能異常、皮瓣壞死、皮下積液及胃腸道反應髮生率比較差異無統計學意義(P＞0.05).治療組跼部複髮率低于對照組[0比20.0％(4/20)],差異有統計學意義(P＜0.05).結論 乳腺癌改良根治術中應用氟尿嘧啶植入劑是安全有效的.
목적 탐토유선암술중방치불뇨밀정식입제간질화료적림상의의.방법 60례행유선암개량근치술환자안술중시부사용불뇨밀정식입제분위치료조(40례)화대조조(20례).대조조상규수술치료,치료조재상규수술후,증류수충세창면,분별재종류구역하방、흉대소기간、액와혈관하0.5 cm균균방치불뇨밀정식입제(제량0.4 g).관찰량조술후골수억제、간신공능、위장도반응、피판배사、피하적액、국부복발등정황.결과 량조골수억제、간신공능이상、피판배사、피하적액급위장도반응발생솔비교차이무통계학의의(P＞0.05).치료조국부복발솔저우대조조[0비20.0％(4/20)],차이유통계학의의(P＜0.05).결론 유선암개량근치술중응용불뇨밀정식입제시안전유효적.
Objective To explore the clinical significance of interstitial chemotherapy applied in breast cancer.Methods Sixty breast cancer patients with modified radical mastectomy were divided into treatment group (40 cases) and control group (20 cases) according to whether using fluorouracil implants.The control group was given conventional treatment.In treatment group,distilled water washed the wound after conventional treatment,and fluorouracil implants (0.4 g) was placed below local tumor,between pectoralis major and pectoralis minor,below 0.5 cm axillary vessel.The bone marrow suppression,liver and renal function,gastrointestinal reaction,skin flap necrosis,subcutaeous hydrops,local recurrence were observed in the 2 groups.Results There were no significant differences in the rates of bone marrow suppression,liver and renal function abnormal,skin flap necrosis,subcutaeous hydrops and gastrointestinal reaction between treatment group and control group (P ＞ 0.05).The rate of local recurrence in treatment group was significantly lower than that in control group [0 vs.20.0％ (4/20)],there was statistical difference (P ＜0.05).Conclusion Intraoperative application of fluorouracil implants is safe and effective in modified radical mastectomy of breast cancer.
