CAJ | 학술논문

目的观察脉冲噪声致纯音听力损失前畸变产物耳声发射（DPOAE）异常的自然转归及硫辛酸对其转归的影响。方法纯音听阈正常、DPOAE异常者26例（41耳），随机分为对照组和治疗组，每组各13例。治疗组给予硫辛酸600mg/日静滴治疗，对照组给予安慰剂治疗，治疗后第2、4、6、8、10天，分别进行纯音听阈及DPOAE检查。结果治疗前两组各对应频率的纯音听阈及DPOAE幅值均无显著差别，DPOAE异常频率主要发生在3、4、6、8kHz。经过治疗后，两组的纯音听阈无明显变化，对照组异常频率的DPOAE的幅值自第8天开始，显著大于治疗前。治疗组异常频率的幅值自第4天开始显著大于治疗前。从治疗后第4天，治疗组异常频率的幅值显著高于对照组对应时间和频率的幅值。结论人耳对脉冲噪声致纯音听力损失前DPOAE幅值异常有一定的自行修复能力，硫辛酸对其恢复有明显的促进作用，提示硫辛酸对爆震性聋有预防作用。
목적관찰맥충조성치순음은력손실전기변산물이성발사（DPOAE）이상적자연전귀급류신산대기전귀적영향。방법순음은역정상、DPOAE이상자26례（41이），수궤분위대조조화치료조，매조각13례。치료조급여류신산600mg/일정적치료，대조조급여안위제치료，치료후제2、4、6、8、10천，분별진행순음은역급DPOAE검사。결과치료전량조각대응빈솔적순음은역급DPOAE폭치균무현저차별，DPOAE이상빈솔주요발생재3、4、6、8kHz。경과치료후，량조적순음은역무명현변화，대조조이상빈솔적DPOAE적폭치자제8천개시，현저대우치료전。치료조이상빈솔적폭치자제4천개시현저대우치료전。종치료후제4천，치료조이상빈솔적폭치현저고우대조조대응시간화빈솔적폭치。결론인이대맥충조성치순음은력손실전DPOAE폭치이상유일정적자행수복능력，류신산대기회복유명현적촉진작용，제시류신산대폭진성롱유예방작용。
Objective To investigate the effect of lipoic acid on abnormally low distortion product otoacoustic emissions (DPOAE) with no hearing loss following military noise exposure. Methods Twenty six (41ears) artillerymen,with normal pure tone hearing thresholds and abnormal DPOAEs amplitudes following military noise exposure were randomly divided into 2 groups. The test group with 13 young adults (21 ears) received intravenous drip of lipoic acid (600 mg/day). The control group with 13 young adults (20 ears) received intravenous drip of placebo. Pure tone audiomety and otoacoustic emission were per-formed on Days 2, 4, 6, 8 and 10 after treatment. Pure tone hearing thresholds and amplitudes of DPOAEs were compared and analyzed. Results Statistical analysis showed that prior to the treatment the amplitudes of DPOAE at 3, 4 , 6 and 8 kHz did not differ significantly between the two groups. DPOAE amplitudes in the control group increased significantly on the 8th day after treatment. The amplitudes in the test group increased significantly on the 4th day after treatment, with a significant differ-ence between the test and control groups. Conclusion Lipoic acid seems to significantly improve DPOAE amplitudes toward normal in individuals with subclinical auditory system impairment caused by military noise exposure.