中华耳科学杂志
中華耳科學雜誌
중화이과학잡지
CHINESE JOURNAL OF OTOLOGY
2013年
3期
357-362
,共6页
噪声是常见的职业性伤害和听力致残因素，预防噪声性耳聋的发生及降低其听觉损害的程度一直是我们研究的重要课题。近年的研究发现噪声暴露可引起耳蜗内活性氧、活性氮自由基及金属蛋白酶增加,毛细胞内DNA损伤，Caspase-3激活，AIF及EndoG的转移等一系列变化，最终导致毛细胞死亡，以凋亡为主。噪声损伤机制的研究为预防和治疗噪声性耳聋开辟了新的思路。
譟聲是常見的職業性傷害和聽力緻殘因素，預防譟聲性耳聾的髮生及降低其聽覺損害的程度一直是我們研究的重要課題。近年的研究髮現譟聲暴露可引起耳蝸內活性氧、活性氮自由基及金屬蛋白酶增加,毛細胞內DNA損傷，Caspase-3激活，AIF及EndoG的轉移等一繫列變化，最終導緻毛細胞死亡，以凋亡為主。譟聲損傷機製的研究為預防和治療譟聲性耳聾開闢瞭新的思路。
조성시상견적직업성상해화은력치잔인소，예방조성성이롱적발생급강저기은각손해적정도일직시아문연구적중요과제。근년적연구발현조성폭로가인기이와내활성양、활성담자유기급금속단백매증가,모세포내DNA손상，Caspase-3격활，AIF급EndoG적전이등일계렬변화，최종도치모세포사망，이조망위주。조성손상궤제적연구위예방화치료조성성이롱개벽료신적사로。
Noise is one of the most common factors causing occupational injury and hearing disability. Therefore, pre-venting noise induced hearing loss (NIHL) and limiting hearing loss are one of the important subjects that we hammer away at. Previous research has shown that noise induces increase of reactive nitrogen free radicals and metalloproteinases in the co-chlea. Injury of DNA, Caspase-3 activation, and translocation of AIF and EndoG occurr in noise damaged hair cells. And these damages lead to hair cell death involving apoptosis and necrosis, although predominantly apoptosis. Understanding cellu-lar and molecular mechanisms of NIHL may open up a new way for the prevention and treatment of this problem.
