河南大学学报（医学版）
河南大學學報（醫學版）
하남대학학보（의학판）
JOURNAL OF HENAN UNIVERSITY (MEDICAL SCIENCE)
2013年
3期
200-204
,共5页
皮百木%齐坤英%穆红梅%张千帆
皮百木%齊坤英%穆紅梅%張韆帆
피백목%제곤영%목홍매%장천범
GM1%视神经病变%预后
GM1%視神經病變%預後
GM1%시신경병변%예후
fungal keratitis%agriculture trauma%Candida albicans
目的评估单唾液酸四己糖神经节苷脂（Monosialotetera-hexosyl ganglioside GM1）与视神经病变预后的相关性。方法采用回顾性病例对照研究，收集首次发病的视神经病变患者143例196眼的临床资料，将可能影响研究对象视力预后的因素：性别、年龄、疾病类别、治疗前（矫正）视力、治疗前发病时间、是否接受GM1治疗为协变量；疗效、首次视力提高的时间、治疗2周后（矫正）视力为因变量，用多元Logistic回归分析探讨GM 1对视神经病变视力预后的影响。结果单因素分析：GM1与视神经病变的疗效、首次视力提高时间、治疗2周后（矫正）视力关联有统计学意义，其 P 值、OR、95％ CI 分别为（P ＝00．00，OR ＝03．13，95％ CI ：01．70-05．78；P ＝00．01， OR ＝03．91，95％ CI ：02．19-06．98；P ＝00．00，OR ＝03．50，95％ CI ：01．96-06．25）。多因素分析：调整其他混杂因素后，GM1与视神经病变的疗效、首次视力提高时间、治疗2周后（矫正）视力显示有明显的促进作用。其调整OR 值，95％ CI 分别为（OR ＝03．11，95％ CI ：01．59-06．06；OR ＝04．24，95％ CI ：02．24，08．05；OR ＝03．08，95％ CI ：01．41-06．71）。结论 GM1对视神经疾病的视力恢复有明显促进作用，有助于获得较好的视力预后。
目的評估單唾液痠四己糖神經節苷脂（Monosialotetera-hexosyl ganglioside GM1）與視神經病變預後的相關性。方法採用迴顧性病例對照研究，收集首次髮病的視神經病變患者143例196眼的臨床資料，將可能影響研究對象視力預後的因素：性彆、年齡、疾病類彆、治療前（矯正）視力、治療前髮病時間、是否接受GM1治療為協變量；療效、首次視力提高的時間、治療2週後（矯正）視力為因變量，用多元Logistic迴歸分析探討GM 1對視神經病變視力預後的影響。結果單因素分析：GM1與視神經病變的療效、首次視力提高時間、治療2週後（矯正）視力關聯有統計學意義，其 P 值、OR、95％ CI 分彆為（P ＝00．00，OR ＝03．13，95％ CI ：01．70-05．78；P ＝00．01， OR ＝03．91，95％ CI ：02．19-06．98；P ＝00．00，OR ＝03．50，95％ CI ：01．96-06．25）。多因素分析：調整其他混雜因素後，GM1與視神經病變的療效、首次視力提高時間、治療2週後（矯正）視力顯示有明顯的促進作用。其調整OR 值，95％ CI 分彆為（OR ＝03．11，95％ CI ：01．59-06．06；OR ＝04．24，95％ CI ：02．24，08．05；OR ＝03．08，95％ CI ：01．41-06．71）。結論 GM1對視神經疾病的視力恢複有明顯促進作用，有助于穫得較好的視力預後。
목적평고단타액산사기당신경절감지（Monosialotetera-hexosyl ganglioside GM1）여시신경병변예후적상관성。방법채용회고성병례대조연구，수집수차발병적시신경병변환자143례196안적림상자료，장가능영향연구대상시력예후적인소：성별、년령、질병유별、치료전（교정）시력、치료전발병시간、시부접수GM1치료위협변량；료효、수차시력제고적시간、치료2주후（교정）시력위인변량，용다원Logistic회귀분석탐토GM 1대시신경병변시력예후적영향。결과단인소분석：GM1여시신경병변적료효、수차시력제고시간、치료2주후（교정）시력관련유통계학의의，기 P 치、OR、95％ CI 분별위（P ＝00．00，OR ＝03．13，95％ CI ：01．70-05．78；P ＝00．01， OR ＝03．91，95％ CI ：02．19-06．98；P ＝00．00，OR ＝03．50，95％ CI ：01．96-06．25）。다인소분석：조정기타혼잡인소후，GM1여시신경병변적료효、수차시력제고시간、치료2주후（교정）시력현시유명현적촉진작용。기조정OR 치，95％ CI 분별위（OR ＝03．11，95％ CI ：01．59-06．06；OR ＝04．24，95％ CI ：02．24，08．05；OR ＝03．08，95％ CI ：01．41-06．71）。결론 GM1대시신경질병적시력회복유명현촉진작용，유조우획득교호적시력예후。
Objective To explore the features of clinic-epidemiological and laboratory diagnosis of fungal keratitis . Methods Three hundred and fifteen patients of different ages having provisional diagnosis of suppurative corneal ulceration were registered for the study . Data were collected through history and slit lamp xamination . Corneal scraping was performed . A portion of each scraping were examined by direct microscopy . Another portion were inoculated directly on to solid culture media . Results Among corneal scraping from 315 patients , the fungus grew in 116 (36 .8% ) . The mean age of patients was 42 .6 years (ranged between 9 and 82 years) .Majority of patients (80;68 .97% ) were from 21 to 50 .Males (72;62 .1% )were affected more often . Majority of the patients ( 80;69% ) was from rural areas . A majority of ( 52;44 .80% ) patients was farmer by profession . Corneal trauma ( 70;60 .4% ) was identified as the leading precipitating factor . Forty eight ( 41 .4% ) patients had corneal injury with vegetative material . The peak incidence observed in the months of October to December followed by March to June . The clinical features were dry , thick and raised grayish white corneal surface in 76 ( 65 .51% ) patients , stromal infiltrates with feathery margins in 64 (55 .2% ) patients , typical satellite lesions in 19 (16 .38% ) patients , hypopyon was present in 70 (60 .3% ) patients .Candida albicans was the most frequent organism which was isolated in eighty (69% ) patients . Conclusion Fungi were found to be the frequent cause of suppurative corneal ulcer following agriculture trauma and Candida albicans were the most commonly isolated pathogen . For the diagnosis of fungal infection , direct microscopic examination with potassium hydroxide 10% is a rapid , inexpensive , and reliable method .
