CAJ | 학술논문

基因表达与调控方面的研究改变了我们对RNA的认识。近年的研发现，长非编码RNA（lncRNA通常大于200碱基而区别于microRNA）参与了一些重要的生命过程，包括染色质修饰、基因转录和转录后调节、蛋白质的活性调节和亚细胞定位以及细胞结构的维持等。新的发现引起越来越多的重视，但这些仍只是非编码RN A的一小部分，人们相信随着研究的深入，lncRNA的调控网络将渐渐浮出水面，不仅对我们认识生命过程的新调节层面有很大帮助，而且具有极大的应用潜力，例如用于基因治疗等方面。
기인표체여조공방면적연구개변료아문대RNA적인식。근년적연발현，장비편마RNA（lncRNA통상대우200감기이구별우microRNA）삼여료일사중요적생명과정，포괄염색질수식、기인전록화전록후조절、단백질적활성조절화아세포정위이급세포결구적유지등。신적발현인기월래월다적중시，단저사잉지시비편마RN A적일소부분，인문상신수착연구적심입，lncRNA적조공망락장점점부출수면，불부대아문인식생명과정적신조절층면유흔대방조，이차구유겁대적응용잠력，례여용우기인치료등방면。
Recent investigations on gene expression and regulation have changed our understanding of the RNA world . Differing from micro RNA in length , long non-coding RNAs ( lncRNA ) are generally considered as transcripts longer than 200 nucleotides . The lncRNAs have been involved in diverse important biological processes such as chromatin remodeling , transcription and post transcription modification , conformation modulation and activity regulation of proteins , sub-cellular location of proteins and maintenance of cell structure . The studies and finding have shed light on a series of novel lncRNA molecules in regulation of gene expression , but it is believed that more lncRNAs will be coming in future . New studies not only provide insight into understanding of lncRNAs regulation network , also confer lncRNAs as potential targets in gene therapy .