CAJ | 학술논문

谷氨酸转运体-1(glutamate transporter-1,GLT-1)是脑组织内的一种重要谷氨酸转运体,可将胞外谷氨酸转运至星形胶质细胞内.在谷氨酰胺合成酶的作用下,谷氨酸转化为可被神经元利用的谷氨酰胺.脑缺血时,细胞外谷氨酸浓度急剧升高,从而对神经元产生兴奋性毒性作用.头孢曲松、亚致死性缺血、低压低氧等预处理均可通过调节GLT-1的表达和改善其功能而起神经保护作用.
곡안산전운체-1(glutamate transporter-1,GLT-1)시뇌조직내적일충중요곡안산전운체,가장포외곡안산전운지성형효질세포내.재곡안선알합성매적작용하,곡안산전화위가피신경원이용적곡안선알.뇌결혈시,세포외곡안산농도급극승고,종이대신경원산생흥강성독성작용.두포곡송、아치사성결혈、저압저양등예처리균가통과조절GLT-1적표체화개선기공능이기신경보호작용.
Glutamate is an essential excitatory neurotransmitter which regulates brain functions.An increase in extracellular glutamate could excessively activate ionotropic glutamate receptors,initiate calcium overload,and lead to cell death after cerebral ischemia.Glutamate transporter-1 (GLT-1) is one of the major glutamate transporters expressed predominantly in astrocytes.Astrocytes also express the enzyme glutamine synthetase (GS) which converts the glutamate to glutamine; the latter is then 'recycled' into neurons.Pretreatment with ceftriaxone (CEF),ischemia and intermittent hypobaric hypoxia could lead to neuroprotection by increasing the expression of GLT-1 and regulating the activity of glutamate transporter in brain.