CAJ | 학술논문

结核分枝杆菌能在宿主体内长期存活，很大一部分原因是能抵抗吞噬体的酸性环境。细菌一方面能抑制吞噬体与溶酶体融合，干扰吞噬体成熟、酸化过程；另一方面也能通过自身功能抵抗吞噬溶酶体内的酸性杀伤作用。本文主要介绍吞噬体的酸化过程及结核分枝杆菌耐酸机制的最新研究进展。
결핵분지간균능재숙주체내장기존활，흔대일부분원인시능저항탄서체적산성배경。세균일방면능억제탄서체여용매체융합，간우탄서체성숙、산화과정；령일방면야능통과자신공능저항탄서용매체내적산성살상작용。본문주요개소탄서체적산화과정급결핵분지간균내산궤제적최신연구진전。
The survival of Mycobacterium tuberculosis (M . tuberculosis) in the host is largely attributed to its ability to resist acidic environment within macrophages . M . tuberculosis inhibits the fusion of phagosomes with lysosomes ,thus arresting the maturation and acidification process of phagosomes .Also ,the bacterium resists the killing within the acidic phagosome-lysosome compartment .Here ,the current understanding of the acidification of phagosomes and acid resistance mechanisms of M . tuberculosis is reviewed .