CAJ | 학술논문

近70年来，由于抗生素的广泛使用，耐药金黄色葡萄球菌不断出现。美国1999～2005年因感染耐甲氧西林金黄色葡萄球菌（MRSA）而入院的患者增加1倍多，其中诊断为败血症的患者增加81．2％。因此，寻找控制耐药菌的新对策十分迫切。目前有望替代抗生素的控菌手段有抗菌肽、噬菌体等。其中，噬菌体的发现早于抗生素，后因抗生素的普及而被忽视。如今，耐药菌株的流行使噬菌体治疗再次受到关注。本文就应用噬菌体及其裂解酶控制金黄色葡萄球菌的研究进展进行综述。
근70년래，유우항생소적엄범사용，내약금황색포도구균불단출현。미국1999～2005년인감염내갑양서림금황색포도구균（MRSA）이입원적환자증가1배다，기중진단위패혈증적환자증가81．2％。인차，심조공제내약균적신대책십분박절。목전유망체대항생소적공균수단유항균태、서균체등。기중，서균체적발현조우항생소，후인항생소적보급이피홀시。여금，내약균주적류행사서균체치료재차수도관주。본문취응용서균체급기렬해매공제금황색포도구균적연구진전진행종술。
In recent years , the wide use of antibiotics leads to the increase in drug-resistant bacteria . In America ,methicillin-resistant Staphylococcus aureus (MRSA )-related hospitalizations were doubled from 1999 to 2005 ,and MRSA-related hospitalizations with confirmed septicemia increased 81 .2% .Therefore ,it is urgent to seek novel countermeasures ,such as antibacterial peptides and bacteriophages to control drug-resistant bacteria .Despite the bacteriophage being discovered earlier than antibiotics ,it was ignored owing to popularity of antibiotics .But now bacteriophages have come back into view as a result of increase in drug-resistant bacteria . Here , the research progress on bacteriophage and lysin in control of Staphylococcus aureus is reviewed .