CAJ | 학술논문

目的评价小剂量重组人脑利钠肽（rhBNP）治疗急性失代偿性心力衰竭的疗效。方法选取急性失代偿性心力衰竭住院患者63例，采用rhBNP治疗，随机分为常规推荐剂量组（n=32）和小剂量组（n=31），观察治疗前后临床症状、体征、左心室舒张末期内径（LVEDd）、左心室射血分数（LVEF）的变化。结果治疗后两组患者症状、体征均明显改善，小剂量组总有效率（90.3%），与常规推荐剂量组（93.8%）比较差异无统计学意义（P＞0.05），两组LVEDd未见明显缩小，而LVEF与治疗前比较明显改善（P＜0.01），组间LVEDd、LVEF比较差异均无统计学意义（均P＞0.05）。结论小剂量rhBNP治疗急性失代偿性心力衰竭效果同常规推荐剂量治疗效果相仿。
목적평개소제량중조인뇌리납태（rhBNP）치료급성실대상성심력쇠갈적료효。방법선취급성실대상성심력쇠갈주원환자63례，채용rhBNP치료，수궤분위상규추천제량조（n=32）화소제량조（n=31），관찰치료전후림상증상、체정、좌심실서장말기내경（LVEDd）、좌심실사혈분수（LVEF）적변화。결과치료후량조환자증상、체정균명현개선，소제량조총유효솔（90.3%），여상규추천제량조（93.8%）비교차이무통계학의의（P＞0.05），량조LVEDd미견명현축소，이LVEF여치료전비교명현개선（P＜0.01），조간LVEDd、LVEF비교차이균무통계학의의（균P＞0.05）。결론소제량rhBNP치료급성실대상성심력쇠갈효과동상규추천제량치료효과상방。
Objective To evaluate the efficacy of smal doses of recombinant hBNP in the treatment of acute decom-pensated heart failure (HF). Methods 63 patients hospitalized for acute decompensated HF were randomly treated with regular dose of rhBNP (n=32) or smal dose of rhBNP (n=31). Clinical symptoms and signs were evaluated, left ventricular end- diastolic diameter (LVEDd) and left ventricular ejection fraction (LVEF) were measured before and after treatment. Results Clinical symptoms and signs were improved significantly in both groups. The overal efficacy was 93.8%in reg-ular dose group and 90.3%in smal dose group. There was no significant difference between them (P>0. 05). LVEF, but not LVEDd, was significantly improved after treatment (P<0.01). LVEDd and LVEF were not significantly different between two groups (P>0. 05). Conclusion Smal dose of rhBNP may improve heart function as wel as regular dose of rhBNP in acute decompensated HF.