CAJ | 학술논문

目的通过临床对脑卒中患者使用西酞普兰治疗方法，观察患者的临床治疗效果以及治疗过程中的不良反应。方法本文研究选取的100例脑卒中后并发抑郁症状的患者是从本院2009年1月～2011年5月中选取的，将100例患者随机分为两组，每组50例。临床治疗过程中同时给予两组患者常规的脑卒中抗血小板药物以及相关脑血管方面的药物治疗。治疗组的患者在原发脑卒中疾病的治疗基础上使用西酞普兰，每天一次口服，剂量为20～40mg。对照组的患者在原发脑卒中疾病的治疗基础上使用帕罗西汀，初始剂量为20mg/d，清晨空腹口服。通过临床对脑卒中患者使用两种不同方法进行疗效观察，分析患者使用西酞普兰治疗后的抑郁情况，并对患者的总显效率进行统计，使用汉密顿抑郁量表对患者治疗前后1、2、4、6周进行观察评分。结果对两组脑卒中并发抑郁症状的患者经过临床治疗后进行比较，治疗组的患者总显效率为92.0%，对照组的患者总显效率为76.0%，两组患者的总显效率比较差异具有统计性（P＜0.05）。并且治疗组的脑卒中后抑郁患者的临床症状有所缓解，说明西酞普兰具有很高的治疗效果。结论通过临床给予脑卒中后抑郁患者西酞普兰治疗后发现，西酞普兰能够有效的改善患者的临床症状，并且在治疗过程中副作用小，并且在患者的心理方面具有良好的改善效果，提高患者的预后情况。
목적통과림상대뇌졸중환자사용서태보란치료방법，관찰환자적림상치료효과이급치료과정중적불량반응。방법본문연구선취적100례뇌졸중후병발억욱증상적환자시종본원2009년1월～2011년5월중선취적，장100례환자수궤분위량조，매조50례。림상치료과정중동시급여량조환자상규적뇌졸중항혈소판약물이급상관뇌혈관방면적약물치료。치료조적환자재원발뇌졸중질병적치료기출상사용서태보란，매천일차구복，제량위20～40mg。대조조적환자재원발뇌졸중질병적치료기출상사용파라서정，초시제량위20mg/d，청신공복구복。통과림상대뇌졸중환자사용량충불동방법진행료효관찰，분석환자사용서태보란치료후적억욱정황，병대환자적총현효솔진행통계，사용한밀돈억욱량표대환자치료전후1、2、4、6주진행관찰평분。결과대량조뇌졸중병발억욱증상적환자경과림상치료후진행비교，치료조적환자총현효솔위92.0%，대조조적환자총현효솔위76.0%，량조환자적총현효솔비교차이구유통계성（P＜0.05）。병차치료조적뇌졸중후억욱환자적림상증상유소완해，설명서태보란구유흔고적치료효과。결론통과림상급여뇌졸중후억욱환자서태보란치료후발현，서태보란능구유효적개선환자적림상증상，병차재치료과정중부작용소，병차재환자적심리방면구유량호적개선효과，제고환자적예후정황。
Objective Through the clinical use of patients with cerebral apoplexy citalopram treatment, observe patients the clinical effects of and in the course of treatment adverse reactions. Methods In this paper, the selected 100 cases of stroke patients with symptoms of depression after concurrent from our hospital from January 2009 to May 2011 months of selection, 100 cases were randomly divided into two groups, and 50 cases. Clinical treatment process and given two groups of patients conventional stroke antiplatelet agents and related cerebrovascular aspects of the drugs. The treatment group in patients with primary stroke disease treatment on the basis of using citalopram, once a day oral, dose of 20 to 40 mg. Patients in the control group primary stroke disease treatment on the basis of using paxil, the initial dose of 20 mg/d, early morning hol ow oral. Through the clinical to patients with cerebral apoplexy using two different clinical observation methods, analyzes patients use citalopram after treatment of depression, and the patients' overal significant efficiency the statistics, use ham-d before and after treatment for patients with 1, 2, 4, 6 weeks observed score. Results Two groups of stroke patients with depression symptoms after clinical treatment carries on the comparison, the treatment group of patients total significant efficiency is 92.0%, and the control group of patients total significant efficiency is 76.0%, two groups of patients' overal significant efficiency compared with statistical differences (P<0.05). And the treatment group stroke patients with clinical symptoms of depression after ease, explain citalopram has the very high treatment effect. Conclusion Citalopram could ameliorate PSD patient’s clinical symptoms with lesser side-effect and make patient’s mentality better and obtain good prognosis.