CAJ | 학술논문

目的分析应用螺内酯治疗老年高血压并发舒张性心力衰竭的临床疗效。方法基础治疗前提下，配合应用螺内酯治疗观察组的84例高血压并发舒张性心力衰竭老年患者；并与基础治疗的76例对照组患者治疗后心脏指标等进行对比。结果治疗后，测量患者6min步行结果，两组患者步行距离均长于治疗前，患者运动耐受性提高，观察组治疗后步行结果为（542±56）m，显著大于对照组（434±45）m，结果具有统计学意义（P＜0.05）；观察组EPFV、APFV、EPFV/APFV、DT值明显改善，患者血浆内脑尿钠肽、醛固酮、肾素及血管紧张素Ⅱ水平均下降，其中脑尿钠肽下降幅度最大，与对照组对比，结果具有统计学意义（P＜0.05）。结论利尿剂螺内酯可有效提升伴有 DHF 的高血压老年患者运动耐受能力，具有改善心脏功能的作用。
목적분석응용라내지치료노년고혈압병발서장성심력쇠갈적림상료효。방법기출치료전제하，배합응용라내지치료관찰조적84례고혈압병발서장성심력쇠갈노년환자；병여기출치료적76례대조조환자치료후심장지표등진행대비。결과치료후，측량환자6min보행결과，량조환자보행거리균장우치료전，환자운동내수성제고，관찰조치료후보행결과위（542±56）m，현저대우대조조（434±45）m，결과구유통계학의의（P＜0.05）；관찰조EPFV、APFV、EPFV/APFV、DT치명현개선，환자혈장내뇌뇨납태、철고동、신소급혈관긴장소Ⅱ수평균하강，기중뇌뇨납태하강폭도최대，여대조조대비，결과구유통계학의의（P＜0.05）。결론이뇨제라내지가유효제승반유 DHF 적고혈압노년환자운동내수능력，구유개선심장공능적작용。
Objective To analyze application of spironolactone therapy in elderly hypertension complicated with diastolic heart failure of clinical efficacy. Methods Foundation treatment under the premise, combined with application of spironolactone treatment group of 84 cases of hypertension complicated with diastolic heart failure in elderly patients;And after the foundation treatment of 76 cases of the control group patients treated cardiac index,etc. Results After treatment, the patients with 6 minutes walk as a result, the two groups patients walking distance is longer than before the treatment, exercise tolerance in patients with increased,observation group after treatment results of (542±56) meters on foot, significantly greater than the control group(434±45)m, the result was statistical y significant (P<0.05); Observation group EPFV and APFV and EPFV/APFV and DT value is obviously improved, patients with brain urine sodium peptide in plasma, blood vessels, renin and aldosterone Wei Yang Ⅱ level decreased, the brain peptide decreased urine sodium largest,compared with control group,the result is statistical y significant (P<0.05). Conclusion Diuretic spironolactone can effectively improve the tolerance of hypertension in elderly patients with DHF movement ability, improve the function of the heart.