CAJ | 학술논문

目的评价艾普拉唑、埃索美拉唑、雷贝拉唑3种质子泵抑制剂（PPI）联合氟哌噻吨美利曲辛（黛力新）治疗功能性消化不良的成本-效果，为临床制定合理用药方案。方法抽取2011年功能性消化不良病例119例随机分为A、B、C三组，三组患者均予黛力新片2片，早晨及中午各服1片。A组45例给予艾普拉唑5mg，早餐前1片，B组40例给予埃索美拉唑20mg，早餐前1片，C组34例给予雷贝拉唑10mg，早餐前1片，三组疗程均为28d。各组结果运用药物经济学原理进行成本-效果分析。结果 A、B、C三组治疗功能性消化不良的有效率分别为95.5%、92.5%、91.2%，三组间无显著性差异（P＞0.05）；成本-效果比（C/E）分别为7.67元、6.06元、6.83元。结论3种方案治疗功能性消化不良有效率及不良反应发生率无显著性差异，但从药物经济学角度考虑，B组方案较佳。
목적평개애보랍서、애색미랍서、뢰패랍서3충질자빙억제제（PPI）연합불고새둔미리곡신（대력신）치료공능성소화불량적성본-효과，위림상제정합리용약방안。방법추취2011년공능성소화불량병례119례수궤분위A、B、C삼조，삼조환자균여대력신편2편，조신급중오각복1편。A조45례급여애보랍서5mg，조찬전1편，B조40례급여애색미랍서20mg，조찬전1편，C조34례급여뢰패랍서10mg，조찬전1편，삼조료정균위28d。각조결과운용약물경제학원리진행성본-효과분석。결과 A、B、C삼조치료공능성소화불량적유효솔분별위95.5%、92.5%、91.2%，삼조간무현저성차이（P＞0.05）；성본-효과비（C/E）분별위7.67원、6.06원、6.83원。결론3충방안치료공능성소화불량유효솔급불량반응발생솔무현저성차이，단종약물경제학각도고필，B조방안교가。
Objective To evaluate the cost-effectiveness of ilaprazole, esomeprazole and rebeprazole in combination with Deanxit for the treatment of functional dyspepsia, in order to a rational medicine regimen in clinical practice.Methods A total of 119 cases with functional dyspepsia in 2011 were randomly divided into 3 groups,A group 45 cses with ilaprazole (5mg), B group 40 cses with esomeprazole (20mg) and C group 34 cses with rebeprazole (10mg) before breakfast, and al patients were assiggned to receive Deanxit (10.5mg) bid after breakfast and lunch. After treatment for 28 days, principle of pharmacoeconomics were adopted to analyze cost-effectiveness of the 3 treatment schemes. Results The effective rates of 3 groups were 95.5%, 92.5%, and 91.2%respectively;the cost-effectiveness ratios(C/E) were 7.67, 6.06and 6.83 yuan respectively. Conclusion There are no obvious difference of these 3 projects in clinical effective rates of the treatment of functional dyspepsia and the adverse reactions, but in perspective of pharmacoeconomics, scheme B is the best.