CAJ | 학술논문

目的观察葛根芩连方对Wa株轮状病毒感染乳鼠腹泻的治疗作用，为深入研究开发葛根芩连方提供实验依据。方法建立Wa株轮状病毒感染昆明小鼠乳鼠腹泻模型和空白对照模型，以葛根芩连方提取物0.78 g/kg进行干预治疗，比较用药前后Wa株轮状病毒感染乳鼠的体征、腹泻率、腹泻程度、小肠及肺的病理形态学等指标变化。结果葛根芩连方提取物0.78 g/kg能够降低乳鼠的腹泻率，减轻腹泻程度，改善感染乳鼠体征及小肠病理形态学变化。结论葛根芩连方具有抗Wa株轮状病毒作用。
목적관찰갈근금련방대Wa주륜상병독감염유서복사적치료작용，위심입연구개발갈근금련방제공실험의거。방법건립Wa주륜상병독감염곤명소서유서복사모형화공백대조모형，이갈근금련방제취물0.78 g/kg진행간예치료，비교용약전후Wa주륜상병독감염유서적체정、복사솔、복사정도、소장급폐적병리형태학등지표변화。결과갈근금련방제취물0.78 g/kg능구강저유서적복사솔，감경복사정도，개선감염유서체정급소장병리형태학변화。결론갈근금련방구유항Wa주륜상병독작용。
Objective To investigate the anti-rotavirus effect of Gegen Qinlian decoction on rotavirus (RV)-inducing diarrhea neonatal mice model, and provide evidences for pharmacological and pharmacodynamic studies. Methods Neonatal diarrhea mice model of Kunming family infected with RV-Wa was developed. Symptom, diarrhea ratio and severity level, histological changes of neonatal mice’s small intestine and lung was assessed after Gegen Qinlian decoction (0.78 g/kg) treatment. Results Diarrhea ratio, diarrhea severity level, histological changes of neonatal mice’s small intestine and lung were obviously decreased after Gegen Qinlian decoction (0.78 g/kg) treatment. Conclusion Gegen Qinlian decoction has anti-rotavirus effect on RV induced diarrhea.