中国中医药信息杂志
中國中醫藥信息雜誌
중국중의약신식잡지
CHINESE JOURNAL OF INFORMATION ON TRADITIONAL CHINESE MEDICINE
2013年
7期
15-17,18
,共4页
慢性特发性血小板减少性紫癜%疏风凉血补肾方%骨髓巨核细胞%分化成熟%转化生长因子-β1
慢性特髮性血小闆減少性紫癜%疏風涼血補腎方%骨髓巨覈細胞%分化成熟%轉化生長因子-β1
만성특발성혈소판감소성자전%소풍량혈보신방%골수거핵세포%분화성숙%전화생장인자-β1
chronic idiopathic thrombocytopenic purpura%expelling wind,cooling blood and invigorating kidney prescription%marrow megakaryocyte%differentiation maturity%TGF-β1
目的观察疏风凉血补肾方对慢性特发性血小板减少性紫癜患者(CITP)骨髓巨核细胞分化成熟及转化生长因子-β1(TGF-β1)的调节作用。方法将50例CITP患者随机分为中药组20例、联合组15例和西药组15例。中药组以疏风凉血补肾方治疗,联合组以疏风凉血补肾方加强的松治疗,西药组以强的松为主治疗,4周为1个疗程,连续治疗3个疗程,观察临床疗效及血小板计数、骨髓巨核细胞总数和构成比例、骨髓TGF-β1水平的变化。结果中药组良效率(55.0%,11/20)显著高于西药组(20.0%,3/15),与联合组(60.0%,9/15)相近；中药组治疗后血小板计数上升(P＜0.01),且优于西药组(P＜0.05),与联合组相似；中药组治疗后骨髓巨核细胞总数降低、产板巨核细胞比例上升(P＜0.01),与联合组相似,而西药组治疗前后无明显差异；中药组、联合组治疗后TGF-β1值降低(P＜0.05),且和西药组治疗后比较差异有统计学意义(P＜0.05)。结论疏风凉血补肾方能有效降低CITP患者TGF-β1水平,促进骨髓巨核细胞分化成熟,从而有效提高血小板计数。
目的觀察疏風涼血補腎方對慢性特髮性血小闆減少性紫癜患者(CITP)骨髓巨覈細胞分化成熟及轉化生長因子-β1(TGF-β1)的調節作用。方法將50例CITP患者隨機分為中藥組20例、聯閤組15例和西藥組15例。中藥組以疏風涼血補腎方治療,聯閤組以疏風涼血補腎方加彊的鬆治療,西藥組以彊的鬆為主治療,4週為1箇療程,連續治療3箇療程,觀察臨床療效及血小闆計數、骨髓巨覈細胞總數和構成比例、骨髓TGF-β1水平的變化。結果中藥組良效率(55.0%,11/20)顯著高于西藥組(20.0%,3/15),與聯閤組(60.0%,9/15)相近；中藥組治療後血小闆計數上升(P＜0.01),且優于西藥組(P＜0.05),與聯閤組相似；中藥組治療後骨髓巨覈細胞總數降低、產闆巨覈細胞比例上升(P＜0.01),與聯閤組相似,而西藥組治療前後無明顯差異；中藥組、聯閤組治療後TGF-β1值降低(P＜0.05),且和西藥組治療後比較差異有統計學意義(P＜0.05)。結論疏風涼血補腎方能有效降低CITP患者TGF-β1水平,促進骨髓巨覈細胞分化成熟,從而有效提高血小闆計數。
목적관찰소풍량혈보신방대만성특발성혈소판감소성자전환자(CITP)골수거핵세포분화성숙급전화생장인자-β1(TGF-β1)적조절작용。방법장50례CITP환자수궤분위중약조20례、연합조15례화서약조15례。중약조이소풍량혈보신방치료,연합조이소풍량혈보신방가강적송치료,서약조이강적송위주치료,4주위1개료정,련속치료3개료정,관찰림상료효급혈소판계수、골수거핵세포총수화구성비례、골수TGF-β1수평적변화。결과중약조량효솔(55.0%,11/20)현저고우서약조(20.0%,3/15),여연합조(60.0%,9/15)상근；중약조치료후혈소판계수상승(P＜0.01),차우우서약조(P＜0.05),여연합조상사；중약조치료후골수거핵세포총수강저、산판거핵세포비례상승(P＜0.01),여연합조상사,이서약조치료전후무명현차이；중약조、연합조치료후TGF-β1치강저(P＜0.05),차화서약조치료후비교차이유통계학의의(P＜0.05)。결론소풍량혈보신방능유효강저CITP환자TGF-β1수평,촉진골수거핵세포분화성숙,종이유효제고혈소판계수。
Objective To observe the effect of expelling wind, cooling blood and invigorating kidney prescription on the marrow megakaryocyte differentiation maturity and TGF-β1 in patients with chronic idiopathic thrombocytopenic purpura (CITP). Methods Fifty CITP patients were randomly divided to three groups, including 20 patients administrated with the expelling wind, cooling blood and invigorating kidney prescription as TCM group, 15 patients with the same decoction and prednisone as combine group, and 15 patients with prednisone as western medicine group, 4 weeks as one treatment course. After 3 courses, the change of platelet counts, marrow megakaryocyte amount, platelet-produced megakaryocyte proportion and TGF-β1 level in the marrow were observed. Results The fine efficiency of TCM group (55.0%, 11/20) excelled western medicine group (20.0%, 3/15) significantly and close to that of combine group (60.0%, 9/15). Platelet counts of TCM group was raised obviously after treatment (P<0.01), better than that of western medicine group (P<0.05), and was similar to that of combine group. The marrow megakaryocyte amount of TCM group was effectively decreased and the platelet-produced megakaryocyte proportion was increased greatly (P<0.01), similar to that of combine group, which of western medicine group had no significant difference between pre-therapy and post-therapy. TGF-β1 of TCM group and combine group degraded obviously (P<0.05) compared with that before treatment, and was significant deviation compared with that of western medicine group (P<0.05). Conclusion The expelling wind, cooling blood and invigorating kidney prescription can effectively degrade the value of TGF-β1 of CITP patients, facilitate the maturity of the marrow megakaryocyte amount and raise the platelet counts.
