CAJ | 학술논문

目的：观察复方大青颗粒一次给药后小鼠急性毒性反应情况，确定最大给药量。方法 I-CR小鼠48只，进行复方大青颗粒急性毒性实验，首次给药1次，连续14天观察复方大青颗粒对小鼠体质量、进食量及饮水量的影响。结果给药后14天，复方大青颗粒对小鼠体质量、进食量和饮水量无明显影响。结论复方大青颗粒给药后连续观察14天，各项指标均未见异常，日最大给药量为56g/kg，相当于临床剂量的311倍。
목적：관찰복방대청과립일차급약후소서급성독성반응정황，학정최대급약량。방법 I-CR소서48지，진행복방대청과립급성독성실험，수차급약1차，련속14천관찰복방대청과립대소서체질량、진식량급음수량적영향。결과급약후14천，복방대청과립대소서체질량、진식량화음수량무명현영향。결론복방대청과립급약후련속관찰14천，각항지표균미견이상，일최대급약량위56g/kg，상당우림상제량적311배。
Objective To observe the acute toxic reaction in mice exposed to one-dose Fufang Daqing granules and to determine its maximum dosage. Methods Forty-eight 48 ICR mice were randomly divided into two control groups(female/male) and two drug groups(female/male),12 mice in each group. Drug groups were given initial dose of 40 mL/kg Fufang Daqing granules. Control groups were given equivalent volume of distilled water. After the ini-tial dose, mice in 4 groups were on normal diet and the body weight,food intake and water intake of mice were recorded for 14 d. Results After 14-day observation,no effect of Fufang Daqing granules on mouse body weight growth,food intake and water intake was found. Conclusion In this study,the maximum dosage of Fufang Daqing granules was 56 g/kg,311 times more than the clinical dose,which did not cause any acute toxicity in mice.