CAJ | 학술논문

目的比较阿立哌唑和利培酮对精神分裂症的疗效，为临床用药提供参考。方法以我院2011年1月～2012年9月收治的120例精神分裂症患者为研究对象，将患者随机分为治疗组和对照组，每组60例。对照组患者应用利培酮，治疗组患者服用阿立哌唑。观察两组的治疗效果以及不良反应。结果治疗组总有效率高于对照组，但是差异不具有统计学意义（ P＞0．05）；两组患者PANSS总分、阳性症状分、阴性症状分、一般精神病理分治疗后明显比治疗前降低（P＜0．05），但是组间比较差异不具有统计学意义（P＞0．05）；治疗组不良反应发生率明显低于对照组（P＜0．05）。结论临床对精神分裂症采用阿立哌唑和利培酮治疗效果均较显著，两种药物疗效相似；但是采用阿立哌唑治疗的不良反应发生率少，因此阿立哌唑治可作为临床的首要选择。
목적비교아립고서화리배동대정신분렬증적료효，위림상용약제공삼고。방법이아원2011년1월～2012년9월수치적120례정신분렬증환자위연구대상，장환자수궤분위치료조화대조조，매조60례。대조조환자응용리배동，치료조환자복용아립고서。관찰량조적치료효과이급불량반응。결과치료조총유효솔고우대조조，단시차이불구유통계학의의（ P＞0．05）；량조환자PANSS총분、양성증상분、음성증상분、일반정신병리분치료후명현비치료전강저（P＜0．05），단시조간비교차이불구유통계학의의（P＞0．05）；치료조불량반응발생솔명현저우대조조（P＜0．05）。결론림상대정신분렬증채용아립고서화리배동치료효과균교현저，량충약물료효상사；단시채용아립고서치료적불량반응발생솔소，인차아립고서치가작위림상적수요선택。
Objective Objective To analyze effect of aripiprazole and risperidone in the treatment of schizo-phrenia ,and provide reference for clinical medication choice .Methods 120 cases with schizophrenia from in-patient department in January 2011 to September 2012 were selected .These patients were randomly di-vided into treatment group and control group , 60 cases in each group .Control group received risperidone , and treatment group received aripiprazole .Curative effect and adverse reaction for two groups were observed and compared .Results Total effective rate for treatment group was obviously higher than control group , but there were no significant difference ( P>0 .05 ) .PANSS score , positive symptoms score , negative symp-toms score and general psychopathology score after treatment were obviously lower than the score before treatment ( P<0 .05 ) , but there were no significant difference ( P>0 .05 ) .Incidence of adverse effect was obviously lower than control group ( P<0.05 ) .Conclusion herapeutic effects of aripiprazole and risperi-done in the treatment of schizophrenia are remarkable and similar .Incidence of adverse reactions of aripi-prazole is less.It can be used as first choice of clinical medication .Therefore, it is worthy of application widely.