北京医学
北京醫學
북경의학
BEIJING MEDICAL JOURNAL
2014年
5期
347-349
,共3页
冠状动脉慢血流现象%体质指数%吸烟%高同型半胱氨酸血症
冠狀動脈慢血流現象%體質指數%吸煙%高同型半胱氨痠血癥
관상동맥만혈류현상%체질지수%흡연%고동형반광안산혈증
Coronary slow flow phenomenon%Body mass index (BMI)%Smoking%Hyperhomocysteine (HHcy)
目的：初步探讨冠状动脉慢血流现象的危险因素。方法回顾性分析我院2010年7月至2013年1月因疑似冠心病行冠状动脉造影检查，明确冠状动脉无明显病变的患者142例，采用心肌梗死溶栓（TIMI）记帧法记录各支冠状动脉的TIMI帧数，冠状动脉平均TIMI帧数大于27为冠状动脉慢血流，将患者分为冠状动脉慢血流组（CSF组，68例）和对照组（74例）。对两组间各项临床指标的差异进行比较，并采用多元Logistic回归分析对冠状动脉慢血流的危险因素进行回归分析。结果 CSF 组与对照组患者高密度脂蛋白胆固醇[（1.02±0.28）mmol/L vs.（1.29±0.33）mmol/L]、血同型半胱氨酸水平[（24.46±2.54）mmol/L vs.（11.81±2.80）mmol/L]、体质指数[（25.91±1.72）kg/m2 vs.（22.82±1.53）kg/m2]、吸烟量[（374.24±182.48）支年 vs.（198.68±116.53）支年]比较差异均有统计学意义（P<0.05），多元Logistic回归分析表明体质指数升高（OR=1.38，95%CI：1.0246~1.8278，P=0.031）、大量吸烟（OR=1.0067，95%CI：1.0025~1.0109，P=0.0017）、高同型半胱氨酸血症（OR=1.12，95%CI：1.1023~1.1291，P=0.0014）为冠状动脉慢血流发生的危险因素。结论体质指数升高、高同型半胱氨酸血症和大量吸烟作为冠状动脉慢血流现象的危险因素，可能参与冠状动脉慢血流现象发生的病理生理过程。
目的：初步探討冠狀動脈慢血流現象的危險因素。方法迴顧性分析我院2010年7月至2013年1月因疑似冠心病行冠狀動脈造影檢查，明確冠狀動脈無明顯病變的患者142例，採用心肌梗死溶栓（TIMI）記幀法記錄各支冠狀動脈的TIMI幀數，冠狀動脈平均TIMI幀數大于27為冠狀動脈慢血流，將患者分為冠狀動脈慢血流組（CSF組，68例）和對照組（74例）。對兩組間各項臨床指標的差異進行比較，併採用多元Logistic迴歸分析對冠狀動脈慢血流的危險因素進行迴歸分析。結果 CSF 組與對照組患者高密度脂蛋白膽固醇[（1.02±0.28）mmol/L vs.（1.29±0.33）mmol/L]、血同型半胱氨痠水平[（24.46±2.54）mmol/L vs.（11.81±2.80）mmol/L]、體質指數[（25.91±1.72）kg/m2 vs.（22.82±1.53）kg/m2]、吸煙量[（374.24±182.48）支年 vs.（198.68±116.53）支年]比較差異均有統計學意義（P<0.05），多元Logistic迴歸分析錶明體質指數升高（OR=1.38，95%CI：1.0246~1.8278，P=0.031）、大量吸煙（OR=1.0067，95%CI：1.0025~1.0109，P=0.0017）、高同型半胱氨痠血癥（OR=1.12，95%CI：1.1023~1.1291，P=0.0014）為冠狀動脈慢血流髮生的危險因素。結論體質指數升高、高同型半胱氨痠血癥和大量吸煙作為冠狀動脈慢血流現象的危險因素，可能參與冠狀動脈慢血流現象髮生的病理生理過程。
목적：초보탐토관상동맥만혈류현상적위험인소。방법회고성분석아원2010년7월지2013년1월인의사관심병행관상동맥조영검사，명학관상동맥무명현병변적환자142례，채용심기경사용전（TIMI）기정법기록각지관상동맥적TIMI정수，관상동맥평균TIMI정수대우27위관상동맥만혈류，장환자분위관상동맥만혈류조（CSF조，68례）화대조조（74례）。대량조간각항림상지표적차이진행비교，병채용다원Logistic회귀분석대관상동맥만혈류적위험인소진행회귀분석。결과 CSF 조여대조조환자고밀도지단백담고순[（1.02±0.28）mmol/L vs.（1.29±0.33）mmol/L]、혈동형반광안산수평[（24.46±2.54）mmol/L vs.（11.81±2.80）mmol/L]、체질지수[（25.91±1.72）kg/m2 vs.（22.82±1.53）kg/m2]、흡연량[（374.24±182.48）지년 vs.（198.68±116.53）지년]비교차이균유통계학의의（P<0.05），다원Logistic회귀분석표명체질지수승고（OR=1.38，95%CI：1.0246~1.8278，P=0.031）、대량흡연（OR=1.0067，95%CI：1.0025~1.0109，P=0.0017）、고동형반광안산혈증（OR=1.12，95%CI：1.1023~1.1291，P=0.0014）위관상동맥만혈류발생적위험인소。결론체질지수승고、고동형반광안산혈증화대량흡연작위관상동맥만혈류현상적위험인소，가능삼여관상동맥만혈류현상발생적병리생리과정。
Objective To investigate the clinical risk factors of coronary slow flow phenomenon. Methods One hundred and forty-two patients with angiographically proven normal coronary arteries admitted during July 2010 to Jan 2013 were included in this study. Coronary flow rates of all patients were documented by Thrombolysis In Myocardial Infarction frame count (TIMI frame count). Patients whose average TIMI frame count greater than 27 were included in the Coronary Slow Flow Phenomenon group (n=68) and others were included as the control group (n=74). Comparison of cate-gorical and continuous variables between the two groups was performed using chi-square and unpaired t-test respectively. Multivariate analysis evaluating predictors of coronary slow flow phenomenon was performed using logistic regression test. Results Body mass index (BMI), hyperhomocysteinemia (HHcy), smoking and low-lipid lipoprotein level were significant-ly higher in the coronary slow flow group compared with the control group (P<0.015). High-density lipoproteins was lower in the coronary slow flow group compared with the control group, the difference was statistically significant (P<0.05). After adjusted with other variables by logistic regression test, BMI (OR 1.38, 95%CI:1.02~1.82, P=0.031), smoking (OR1.0067, 95%CI:1.0025~1.0109, P=0.0017) and HHcy (OR 1.12, 95%CI:1.0023~1.1291, P=0.0014) were proven to be the risk factors for slow coronary flow. Conclusion Increasing in BMI, smoking and HHcy may play a role in the pathogenesis of slow coronary flow.
