中国人群吸烟与喉癌关系的 Meta 分析
중국인군흡연여후암관계적 Meta 분석
Meta-analysis on the relationship between smoking and the risk of laryngeal cancer among Chinese population
  • 万方数据
    中国健康教育 중국건강교육
    CHINESE JOURNAL OF HEALTH EDUCATION
    2013年 8期 699-703 ,共5页

    邰隽%李爱东%黄育北%房居高%黄志刚%于振坤%陈晓红%周维国%饶远生%肖潇%龙婷%王蓔%韩阳%刘悄吟%倪鑫

    태준%리애동%황육북%방거고%황지강%우진곤%진효홍%주유국%요원생%초소%룡정%왕요%한양%류초음%예흠

    喉癌%吸烟%meta 分析 喉癌%吸煙%meta 分析
    후암%흡연%meta 분석
    Laryngeal cancer%Smoking%Systematic review%Meta-analysis
    目的综合评价中国人群吸烟与喉癌之间的关系及关联强度，为我国喉癌的防治策略提供依据。方法在 CNKI、万方、维普、PubMed、ScienceDirect、SpringerLink、Wiley、ProQuest 等数据库中系统检索截止2013年1月之前国内外发表的相关研究文献。所有文献检索、文献选取、文献信息的提取及文献质量评价均由两人独立进行。根据研究之间的异质性大小采用合适的方法来合并相关结果。结果纳入合格研究文献16篇，喉癌患者2730例，对照3224例。吸烟与喉癌发病关系的合并 OR 值为4.08（95％ CI：2.90～5.26；I2＝86.7％，P ＜0.001）。很少吸烟者及经常吸烟者发生喉癌的 OR 值为分别为5.90（95％ CI：3.05～11.41）及13.30（95％ CI：8.03～22.03）。结合漏斗图的结果，尚不能认为目前纳入的研究存在发表偏倚（Egger，P ＝0.402；Begg，P ＝0.784）。结论在中国，吸烟会显著增加喉癌的发病风险，而且随着吸烟量的增加，喉癌的风险可能更高。
    목적종합평개중국인군흡연여후암지간적관계급관련강도，위아국후암적방치책략제공의거。방법재 CNKI、만방、유보、PubMed、ScienceDirect、SpringerLink、Wiley、ProQuest 등수거고중계통검색절지2013년1월지전국내외발표적상관연구문헌。소유문헌검색、문헌선취、문헌신식적제취급문헌질량평개균유량인독립진행。근거연구지간적이질성대소채용합괄적방법래합병상관결과。결과납입합격연구문헌16편，후암환자2730례，대조3224례。흡연여후암발병관계적합병 OR 치위4.08（95％ CI：2.90～5.26；I2＝86.7％，P ＜0.001）。흔소흡연자급경상흡연자발생후암적 OR 치위분별위5.90（95％ CI：3.05～11.41）급13.30（95％ CI：8.03～22.03）。결합루두도적결과，상불능인위목전납입적연구존재발표편의（Egger，P ＝0.402；Begg，P ＝0.784）。결론재중국，흡연회현저증가후암적발병풍험，이차수착흡연량적증가，후암적풍험가능경고。
    Objective To evaluate the relationship and the strength of association between smoking and the risk of laryngeal cancer among Chinese population,providing support for preventing laryngeal cancer in China.Methods A sys-tematic search of electronic databases (including CNKI,VIP,Wanfang,Pubmed,ScienceDirect,SpringerLink,Wiley, ProQuest)up to now was performed.Two reviewers independently conducted the literature search,study eligibility,data extraction and quality evaluation.Pooled odds ratio (OR)value and 95% CI value were calculated with suitable methods ac-cording to the heterogeneity among different studies.Results 16 studies involving 2730 cases of laryngeal cancer and 3224 controls were included in this review.The pooled OR between smoking and the risk of laryngeal cancer was 4.08 (95% CI:2.90 -5.26;I2 =86.7%,P <0.001).Re-analysis showed that the pooled ORs were 5.90 (95% CI:3.05 -11.41)for seldom smokers and 13.30 (95% CI:8.03 -22.03)for frequent smokers respectively.Combined with the funnel plot,no significant publication bias is found among the included studies (Egger,P =0.402;Begg,P =0.784).Conclusion Smoking is significantly positively associated with increased risk of laryngeal cancer,and the risk increased as the dose of smoking increases.
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