世界中医药
世界中醫藥
세계중의약
WORLD CHINESE MEDICINE
2013年
8期
926-928
,共3页
冬凌草片%榄香烯%膀胱灌注%浅表性膀胱癌
鼕凌草片%欖香烯%膀胱灌註%淺錶性膀胱癌
동릉초편%람향희%방광관주%천표성방광암
Donglingcao tablets%Elemene%Intravesical instillation%Superficial bladder cancer
目的：观察分析冬凌草片辅助榄香烯膀胱灌注预防浅表性膀胱癌术后复发的前瞻性临床疗效及安全性。方法：选取2008年6月至2010年6月我院收治的75例浅表性膀胱癌患者，均采用保留膀胱经尿道肿瘤切除术。行前瞻性、随机对照临床研究，术后将其随机分为对照组和治疗组。治疗组38例，术后口服冬凌草片，术后1周行榄香烯膀胱内灌注；对照组37例，术后1周行榄香烯膀胱内灌注。随访2年，观察患者肿瘤复发情况及不良反应。结果：对照组平均随访26.6个月，2年复发率16.22％。治疗组平均随访29.8月，2年复发率10.53％，两组患者2年复发率相比，差异有统计学意义（P＜0.05）。两组间的不良反应比较无统计学意义（P＞0.05）。结论：冬凌草片辅助榄香烯膀胱灌注预防浅表性膀胱癌术后复发有良好疗效，不良反应少，值得在临床广泛推广。
目的：觀察分析鼕凌草片輔助欖香烯膀胱灌註預防淺錶性膀胱癌術後複髮的前瞻性臨床療效及安全性。方法：選取2008年6月至2010年6月我院收治的75例淺錶性膀胱癌患者，均採用保留膀胱經尿道腫瘤切除術。行前瞻性、隨機對照臨床研究，術後將其隨機分為對照組和治療組。治療組38例，術後口服鼕凌草片，術後1週行欖香烯膀胱內灌註；對照組37例，術後1週行欖香烯膀胱內灌註。隨訪2年，觀察患者腫瘤複髮情況及不良反應。結果：對照組平均隨訪26.6箇月，2年複髮率16.22％。治療組平均隨訪29.8月，2年複髮率10.53％，兩組患者2年複髮率相比，差異有統計學意義（P＜0.05）。兩組間的不良反應比較無統計學意義（P＞0.05）。結論：鼕凌草片輔助欖香烯膀胱灌註預防淺錶性膀胱癌術後複髮有良好療效，不良反應少，值得在臨床廣汎推廣。
목적：관찰분석동릉초편보조람향희방광관주예방천표성방광암술후복발적전첨성림상료효급안전성。방법：선취2008년6월지2010년6월아원수치적75례천표성방광암환자，균채용보류방광경뇨도종류절제술。행전첨성、수궤대조림상연구，술후장기수궤분위대조조화치료조。치료조38례，술후구복동릉초편，술후1주행람향희방광내관주；대조조37례，술후1주행람향희방광내관주。수방2년，관찰환자종류복발정황급불량반응。결과：대조조평균수방26.6개월，2년복발솔16.22％。치료조평균수방29.8월，2년복발솔10.53％，량조환자2년복발솔상비，차이유통계학의의（P＜0.05）。량조간적불량반응비교무통계학의의（P＞0.05）。결론：동릉초편보조람향희방광관주예방천표성방광암술후복발유량호료효，불량반응소，치득재림상엄범추엄。
Objective:To research on effect of Donglingcao tablets on top of intravesical infusion of Elemene for preventing postoperative relapse of superficial bladder cancer .Methods:75 postoperative patients with intermediate and high-risk urothelial tumor of the bladder that performed transurethral resection of the bladder tumor , were randomly assigned into 2 groups.Observation group ( 38 patients) were given Donglingcao tablets on top of intravesical infusion of Elemene , and control group (37 patients) were given intravesical infu-sion of Elemene only.The patients were followed up for clinical , analytical and cystoscopic evaluations for 2 years.The tumor recurrence rates and side effects after the treatment were evaluated .Results:The recurrence rates were 16.22%of control group 2 years after opera-tion.The recurrence rates were 10.53%of observation group 2 years after operation.The recurrence rate of observation group was lower than that of control group.And there were no significant difference of adverse reactions in two groups (P >0.05).Conclusion:Donglingcao tablets on top of intravesical infusion of Elemene is safe and effective in preventing superficial bladder tumor recurrence after surgery.
