CAJ | 학술논문

目的：观察五味麝香丸对模型动物的抗炎镇痛作用。方法：制造大鼠、小鼠炎症模型和疼痛模型，观察五味麝香丸的抗炎镇痛作用。结果：五味麝香丸0.021 g/kg和0.010 g/kg两个剂量对组织胺所致大鼠足趾肿胀有明显抑制作用，与对照组相比差异有统计学意义(P＜0.05)；五味麝香丸0.030 g/kg和0.015g/kg两个剂量组对二甲苯所致小鼠耳壳肿胀和冰醋酸所致小鼠腹腔毛细血管通透性增加有明显抑制作用，与对照组相比差异有统计学意义(P＜0.05)。五味麝香丸0.030 g/kg和0.015 g/kg两个剂量组对冰醋酸所致小鼠扭体反应有明显抑制作用，与对照组相比差异有统计学意义(P＜0.01)；五味麝香丸0.030 g/kg剂量组对小鼠热板痛阈值有明显提高作用，其作用在给药后60分钟和90分钟时较明显，与对照组相比差异有统计学意义(P＜0.05)。结论：五味麝香丸具有明显的抗炎和镇痛作用。
목적：관찰오미사향환대모형동물적항염진통작용。방법：제조대서、소서염증모형화동통모형，관찰오미사향환적항염진통작용。결과：오미사향환0.021 g/kg화0.010 g/kg량개제량대조직알소치대서족지종창유명현억제작용，여대조조상비차이유통계학의의(P＜0.05)；오미사향환0.030 g/kg화0.015g/kg량개제량조대이갑분소치소서이각종창화빙작산소치소서복강모세혈관통투성증가유명현억제작용，여대조조상비차이유통계학의의(P＜0.05)。오미사향환0.030 g/kg화0.015 g/kg량개제량조대빙작산소치소서뉴체반응유명현억제작용，여대조조상비차이유통계학의의(P＜0.01)；오미사향환0.030 g/kg제량조대소서열판통역치유명현제고작용，기작용재급약후60분종화90분종시교명현，여대조조상비차이유통계학의의(P＜0.05)。결론：오미사향환구유명현적항염화진통작용。
Objective:To explore the anti-inflammation and analgesia actions of WuWei SheXiang pills on the animal models. Method:The rats and mice models suffering from inflammation and pain were established through observing the effects of WuWei SheXiang pills. Result:WuWei SheXiang pills showed the inhibition to toe swollen induced by histamine at the doses of 0.021g/kg and 0.010 g/kg obviously, the difference had statistical meaning com-pared with the control group (P<0.05);it also could inhibit ear-swollen caused by dimethylbenzene and the increase of capillary vessel permeability induced by glacial acetic acid remarkably at the doses of 0.030g/kg and 0.015g/kg, the differences had statistical meaning compared with the control group (P<0.05). The results of analgesia tests demonstrated that the drug could also inhibit the writhing test of the mice induced by acetic acid at the doses of 0.030 g/kg and 0.015 g/kg, the differences had statistical meaning compared with the control group (P<0.01); it could improve hot-plate threshold of the mice at the dose of 0.030 g/kg, it took effects in 60 minutes and 90 minutes after medication notably, the differences had statistical meaning compared with the control group (P<0.05). Conclu-sion:WuWei SheXiang pills show the function of better anti-inflammation and analgesia.