西部中医药
西部中醫藥
서부중의약
GANSU JOURNAL OF TRADITIONAL CHINESE MEDICINE
2013年
8期
11-14
,共4页
李雪嫣%张李峰%桂曼曼%鲍英存%杜娟%蒲建中%程卫东
李雪嫣%張李峰%桂曼曼%鮑英存%杜娟%蒲建中%程衛東
리설언%장리봉%계만만%포영존%두연%포건중%정위동
细胞免疫%免疫抑制%玉屏风散%复芪止汗颗粒
細胞免疫%免疫抑製%玉屏風散%複芪止汗顆粒
세포면역%면역억제%옥병풍산%복기지한과립
cellular immunity%immunosuppression%YuPingFengSan%FuQiZ hiHan granules
目的:比较复方玉屏风散口服液和复芪止汗颗粒在提高免疫抑制小鼠细胞免疫功能方面的差异。方法:小鼠腹腔注射环磷酰胺制备免疫抑制模型,分别以生理盐水、玉屏风散口服液(6 g/kg·d)和复芪止汗颗粒(27 g/kg·d)灌胃,测定其胸腺和脾脏指数、T淋巴细胞增殖指数,T淋巴细胞亚群、INF-γ水平及腹腔巨噬细胞吞噬指数。结果:玉屏风散口服液和复芪止汗颗粒均能提高免疫抑制模型小鼠的胸腺和脾脏指数、T淋巴细胞增殖指数,CD3+、CD4+和CD8+淋巴细胞百分比及血清INF-γ水平,但两者之间比较差异具有统计学意义(P<0.05)。结论:玉屏风散口服液和复芪止汗颗粒均能提高免疫抑制小鼠的细胞免疫功能,但玉屏风散口服液效果优于复芪止汗颗粒。
目的:比較複方玉屏風散口服液和複芪止汗顆粒在提高免疫抑製小鼠細胞免疫功能方麵的差異。方法:小鼠腹腔註射環燐酰胺製備免疫抑製模型,分彆以生理鹽水、玉屏風散口服液(6 g/kg·d)和複芪止汗顆粒(27 g/kg·d)灌胃,測定其胸腺和脾髒指數、T淋巴細胞增殖指數,T淋巴細胞亞群、INF-γ水平及腹腔巨噬細胞吞噬指數。結果:玉屏風散口服液和複芪止汗顆粒均能提高免疫抑製模型小鼠的胸腺和脾髒指數、T淋巴細胞增殖指數,CD3+、CD4+和CD8+淋巴細胞百分比及血清INF-γ水平,但兩者之間比較差異具有統計學意義(P<0.05)。結論:玉屏風散口服液和複芪止汗顆粒均能提高免疫抑製小鼠的細胞免疫功能,但玉屏風散口服液效果優于複芪止汗顆粒。
목적:비교복방옥병풍산구복액화복기지한과립재제고면역억제소서세포면역공능방면적차이。방법:소서복강주사배린선알제비면역억제모형,분별이생리염수、옥병풍산구복액(6 g/kg·d)화복기지한과립(27 g/kg·d)관위,측정기흉선화비장지수、T림파세포증식지수,T림파세포아군、INF-γ수평급복강거서세포탄서지수。결과:옥병풍산구복액화복기지한과립균능제고면역억제모형소서적흉선화비장지수、T림파세포증식지수,CD3+、CD4+화CD8+림파세포백분비급혈청INF-γ수평,단량자지간비교차이구유통계학의의(P<0.05)。결론:옥병풍산구복액화복기지한과립균능제고면역억제소서적세포면역공능,단옥병풍산구복액효과우우복기지한과립。
Objective: To compare the differences between compound YuPingFengSan oral liquid and FuQi ZhiHan granules in improving cellular immunity of mice with immunosuppression. Method: The models of immunosuppression mice were made through peritoneal injection of cyclophosphamide and then received gastric administration of physiological saline, YuPingFengSan oral liquid[6 g/(kg·d)] and FuQi ZhiHan granules[27 g/(kg·d]. Thymus and spleen index, proliferation index of T-lymphocyte, sub T-lymphocyte, the level of INF-γ and phagocytic indexes of peritoneal macrophages were tested. Result: Both of the drugs could improve thymus and spleen index, proliferation index of T-lymphocyte, lymphocytic percentages of CD3+, CD4+and CD8+as well as the level of serum INF-γ, the difference between both drugs had statistical meaning (P<0.05). Conclusion:YuPingFengSan oral liquid and FuQi ZhiHan granules could improve cellular immunity of mice with immunosuppression, but clinical efficacy of YuPingSan oral liquid is better than FuQi ZhiHan granules.