CAJ | 학술논문

目的研究帕金森病患者非运动症状(NMS)的分布及其对生活质量的影响。方法对50例帕金森病患者及50名正常人分别用NMS问卷和健康调查简表(SF-36)进行调查，并行Spearman相关分析。结果帕金森病患者98%伴有NMS，以近记忆力下降、便秘、不宁腿发生率最高；与正常人比较，除性欲改变、性生活困难和恶心或呕吐3项外，均有显著性差异(P<0.05)。SF-36的8个维度两组比较均有显著性差异(P<0.05)。便秘、近记忆力下降、注意力下降、不宁腿和睡眠障碍与SF-36评分相关(P<0.05)。结论帕金森病患者中NMS的发生率很高，并对生活质量有很大影响。
목적연구파금삼병환자비운동증상(NMS)적분포급기대생활질량적영향。방법대50례파금삼병환자급50명정상인분별용NMS문권화건강조사간표(SF-36)진행조사，병행Spearman상관분석。결과파금삼병환자98%반유NMS，이근기억력하강、편비、불저퇴발생솔최고；여정상인비교，제성욕개변、성생활곤난화악심혹구토3항외，균유현저성차이(P<0.05)。SF-36적8개유도량조비교균유현저성차이(P<0.05)。편비、근기억력하강、주의력하강、불저퇴화수면장애여SF-36평분상관(P<0.05)。결론파금삼병환자중NMS적발생솔흔고，병대생활질량유흔대영향。
Objective To investigate the status about non-motor symptoms (NMS) in Parkinson's disease (PD) patients and the effect on quality of life. Methods 50 PD patients and 50 normal controls were investigated with the NMS questionnaire and the Healthy Survey short form (SF-36), and analysed with Spearman correlation. Results 98% of PD patients presented NMS, and recent memory loss, restless legs, constipation were the most frequent. All the NMS were more frequent than in the controls (P<0.05) except sexual desire, sexual difficulties and nausea or vomiting. All the dimensions of SF-36 were significantly different between the groups (P<0.05). The symptoms of constipa-tion, decline in recent memory, decreased attention, restless legs and sleep disorders correlated with the scores of SF-36 (P<0.05). Conclu-sion NMS is common in PD patients, and impacts their quality of life.