CAJ | 학술논문

目的探讨新疆喀什地区伽师县克孜勒博依乡维吾尔族妇女人群 HPV （Human papilloma virus ，人乳头瘤病毒）感染情况及 HPV感染与不同程度宫颈病变的关系，为制定新疆农村妇女宫颈癌防治对策和措施提供科学依据。方法于2011年6月15日-7月15日在伽师县克孜勒博依乡选择30～60岁的1300例维吾尔族妇女为主要研究对象。所有研究对象接受问卷调查、妇检、HPV-DNA检测（HC-Ⅱ）、液基细胞学检查，对于 HPV-DNA检测（HC-Ⅱ）与液基细胞学检查任意一项阳性者行阴道镜下宫颈活组织检查。结果（1）喀什地区伽师县克孜勒博依乡妇女 H PV总阳性率为10．31％。宫颈液基细胞异常率为2．77％。（2）不同宫颈病变脱落细胞中 H PV DNA 负荷量中位数最高为宫颈癌，最低为慢性宫颈炎，慢性宫颈炎组与CIN组及宫颈癌组比较，差异有统计学意义（P ＜0．05）；CIN各组和宫颈癌组之间比较差异无统计学意义（P ＞0．05）。（3）HPV感染组中，细胞学阳性率分别为：ASCUS 42．11％、ASC-H 50％、LSIL 66．7％、HSIL 66．7％、浸润癌100％，与 HPV非感染组阳性率比较差异有统计学意义（P ＜0．05）；随着宫颈病变程度的加重，HPV阳性率也逐渐升高，且在各种宫颈细胞学病例中HPV感染的阳性率差异有统计学意义（P＜0．05）。结论 HPV感染率与宫颈病变严重程度有关；宫颈细胞学异常与H PV感染有关；高病毒负荷量可能比患宫颈癌及宫颈上皮内瘤变的风险更大，但是不能用来预测宫颈病变的严重程度。
목적탐토신강객십지구가사현극자륵박의향유오이족부녀인군 HPV （Human papilloma virus ，인유두류병독）감염정황급 HPV감염여불동정도궁경병변적관계，위제정신강농촌부녀궁경암방치대책화조시제공과학의거。방법우2011년6월15일-7월15일재가사현극자륵박의향선택30～60세적1300례유오이족부녀위주요연구대상。소유연구대상접수문권조사、부검、HPV-DNA검측（HC-Ⅱ）、액기세포학검사，대우 HPV-DNA검측（HC-Ⅱ）여액기세포학검사임의일항양성자행음도경하궁경활조직검사。결과（1）객십지구가사현극자륵박의향부녀 H PV총양성솔위10．31％。궁경액기세포이상솔위2．77％。（2）불동궁경병변탈락세포중 H PV DNA 부하량중위수최고위궁경암，최저위만성궁경염，만성궁경염조여CIN조급궁경암조비교，차이유통계학의의（P ＜0．05）；CIN각조화궁경암조지간비교차이무통계학의의（P ＞0．05）。（3）HPV감염조중，세포학양성솔분별위：ASCUS 42．11％、ASC-H 50％、LSIL 66．7％、HSIL 66．7％、침윤암100％，여 HPV비감염조양성솔비교차이유통계학의의（P ＜0．05）；수착궁경병변정도적가중，HPV양성솔야축점승고，차재각충궁경세포학병례중HPV감염적양성솔차이유통계학의의（P＜0．05）。결론 HPV감염솔여궁경병변엄중정도유관；궁경세포학이상여H PV감염유관；고병독부하량가능비환궁경암급궁경상피내류변적풍험경대，단시불능용래예측궁경병변적엄중정도。
Objective By investigating the infection of human papillomavirus (HPV ) and distribution of HPV subtypes in population ,and the relation between HPV infections with squamous intraepithelial lesion in the Kizilbuy village in Kashgar Xinjiang ,provides a scientific basis for the development of cervical canc-er prevention strategies and measures .Methods A population based cervical cancer screening was done from June15 to July 15 ,2011 ,among 1 ,300 women in Kizilbuy township of Payzawat ,Kashgar ,Xinjiang ranging in age from 30 to 60 .And all of the objectives were carried through questionnaire performing , HPV-DNA testing ,liquid-based Cytology the patient who had positive for the HPV-DNA testing and liq-uid-based cytology was put up colposcopic biopsy .Results (1) 134(10 .31% ) women in all were HPV positive ,diagnosis ≥ASCUS by liquid-based cytology was 2 .77% (36/1 ,300) .(2) In different cervical le-sions ,the highest median load shedding of HPV is cervical cancer ,and the lowest is chronic cervicitis . When Chronic cervicitis group compared with the CIN group ,the difference was statistically significant (P<0 .05);Comparison between the CIN group and cervical cancer group was not statistically significant (P>0 .05) .(3) In HPV infected group ,positive ratio of cytologic test was 42 .11% in ASCUS ,50% in ASC-H ,66 .7% in LSIL ,66 .7% in HSIL and 100% in Invasive carcinoma .There was a statistically sig-nificance in this group .Conclusion The positive rate of HPV related to the severity of cervical disease , the positive rate of cytology related to HPV positivity ;High viral load is likely to suffer a greater risk of cervical cancer and cervical intraepithelial neoplasia ,but can not be used to predict the severity of cervical lesions .