CAJ | 학술논문

目的探讨新疆医科大学附属肿瘤医院医院药品不良反应（ADR ）发生的相关因素与特点，促进临床合理用药，预防或减少ADR的发生。方法依据2010年1月-2013年3月上报的200例ADR报告，分别按照患者年龄、性别、引起ADR的药品、给药途径及ADR的临床表现等方面进行统计分析。结果200例ADR报告中，ADR发生集中在40～49岁年龄段；女性患者发生ADR例次远高于男性患者；引发ADR的药品中，以抗肿瘤药为主（30．50％），其次为中药制剂（22．50％）；主要给药途径是静脉给药（93．5％）；引起ADR的前10种药品中，以注射用奈达铂为主（7．0％），其次为奥沙利铂注射液（6．5％）和紫杉醇注射液（4．0％）；ADR以全身性损害为主。结论 ADR的发生与多种因素相关，应加强抗肿瘤药物 ADR的监测工作，做好相应的防治工作，以保证用药安全。
목적탐토신강의과대학부속종류의원의원약품불량반응（ADR ）발생적상관인소여특점，촉진림상합리용약，예방혹감소ADR적발생。방법의거2010년1월-2013년3월상보적200례ADR보고，분별안조환자년령、성별、인기ADR적약품、급약도경급ADR적림상표현등방면진행통계분석。결과200례ADR보고중，ADR발생집중재40～49세년령단；녀성환자발생ADR례차원고우남성환자；인발ADR적약품중，이항종류약위주（30．50％），기차위중약제제（22．50％）；주요급약도경시정맥급약（93．5％）；인기ADR적전10충약품중，이주사용내체박위주（7．0％），기차위오사리박주사액（6．5％）화자삼순주사액（4．0％）；ADR이전신성손해위주。결론 ADR적발생여다충인소상관，응가강항종류약물 ADR적감측공작，주호상응적방치공작，이보증용약안전。
Objective To analyze the occurrence of adverse drug reactions (ADR) in our hospital and to promote clinical rational drug use ,to prevent or decrease the occurrence of ADR .Methods 200 cases with ADR reports were collected from January 2010 to March 2013 in our hospital .Patients′age and sex ,types of drugs ,administration route and clinical manifestations were analyzed .Results Among the 200 ADR ca-ses ,ADR occurs concentrated in the 40 to 49 age group;female patients ADR cases is much higher than male patients ,induced ADR of drugs ,mainly in oncology (30 .50% ) ,followed by traditional Chinese medi-cine (22 .50% );major route of administration is intravenous administration (93 .5% ) ,causing the ADR top 10 drugs ,mainly by injection nedaplatin (7 .0% ) ,followed by oxaliplatin injection (6 .5% ) and pacli-taxel injection (4 .0% ) .The main clinical manifestations of ADRs were systemic damages .Conclusion The occurrence of ADR is associated with many factors .Monitoring of ADR of antineoplastics and preven-ting ADR should be strengthened in order to ensure the safety of drug usage .