新疆医科大学学报
新疆醫科大學學報
신강의과대학학보
JOURNAL OF XINJIANG MEDICAL UNIVERSITY
2013年
9期
1301-1303
,共3页
克迪雅·艾海提%徐怡%穆朝东
剋迪雅·艾海提%徐怡%穆朝東
극적아·애해제%서이%목조동
直肠癌%CA19-9%CEA%CA72-4
直腸癌%CA19-9%CEA%CA72-4
직장암%CA19-9%CEA%CA72-4
rectal cancer%CA19-9%CEA%CA72-4
目的探讨血清中肿瘤标记物在直肠癌诊断中的临床应用价值。方法选取136例直肠癌患者(直肠癌组),根据临床分期,将直肠癌分为Ⅰ期组、Ⅱ期组、Ⅲ期组、Ⅳ期组,另选取肠道良性病变者65例作为对照组,对各组3种血清肿瘤标志物:血清糖蛋白抗原19-9(CA19-9)、癌胚抗原(CEA)、糖蛋白抗原72-4(CA72-4)水平及相关值进行比较。结果直肠癌组 CA19-9、CEA、CA72-4浓度分别为(49.87±16.33)IU/mL、(14.37±15.12)μg/L、(21.27+18.11) IU/mL ,且均明显高于对照组(P <0.05)。3种血清肿瘤标记物CA19-9、CEA、CA72-4中,CA72-4的敏感度(SEN)最高(55.1%),CEA的特异度(SPE)最高(78.5%),CA72-4的约登指数(YI)最高(24.3%),CEA的阳性预测值(+PV )最高(79.7%)。经平行试验后,CA19-9+CEA+CA72-4的SEN升高到80.9%,序列试验后,CA19-9+CEA+CA72-4的SPE升高到93.8%。Ⅲ期组、Ⅳ期组血清CA19-9、CEA、CA72-4浓度均明显高于Ⅰ期组、Ⅱ期组浓度,其浓度的高低与直肠癌的临床分期存在相关性。结论 CA19-9、CEA、CA72-4可用于辅助诊断直肠癌及预测临床分期。
目的探討血清中腫瘤標記物在直腸癌診斷中的臨床應用價值。方法選取136例直腸癌患者(直腸癌組),根據臨床分期,將直腸癌分為Ⅰ期組、Ⅱ期組、Ⅲ期組、Ⅳ期組,另選取腸道良性病變者65例作為對照組,對各組3種血清腫瘤標誌物:血清糖蛋白抗原19-9(CA19-9)、癌胚抗原(CEA)、糖蛋白抗原72-4(CA72-4)水平及相關值進行比較。結果直腸癌組 CA19-9、CEA、CA72-4濃度分彆為(49.87±16.33)IU/mL、(14.37±15.12)μg/L、(21.27+18.11) IU/mL ,且均明顯高于對照組(P <0.05)。3種血清腫瘤標記物CA19-9、CEA、CA72-4中,CA72-4的敏感度(SEN)最高(55.1%),CEA的特異度(SPE)最高(78.5%),CA72-4的約登指數(YI)最高(24.3%),CEA的暘性預測值(+PV )最高(79.7%)。經平行試驗後,CA19-9+CEA+CA72-4的SEN升高到80.9%,序列試驗後,CA19-9+CEA+CA72-4的SPE升高到93.8%。Ⅲ期組、Ⅳ期組血清CA19-9、CEA、CA72-4濃度均明顯高于Ⅰ期組、Ⅱ期組濃度,其濃度的高低與直腸癌的臨床分期存在相關性。結論 CA19-9、CEA、CA72-4可用于輔助診斷直腸癌及預測臨床分期。
목적탐토혈청중종류표기물재직장암진단중적림상응용개치。방법선취136례직장암환자(직장암조),근거림상분기,장직장암분위Ⅰ기조、Ⅱ기조、Ⅲ기조、Ⅳ기조,령선취장도량성병변자65례작위대조조,대각조3충혈청종류표지물:혈청당단백항원19-9(CA19-9)、암배항원(CEA)、당단백항원72-4(CA72-4)수평급상관치진행비교。결과직장암조 CA19-9、CEA、CA72-4농도분별위(49.87±16.33)IU/mL、(14.37±15.12)μg/L、(21.27+18.11) IU/mL ,차균명현고우대조조(P <0.05)。3충혈청종류표기물CA19-9、CEA、CA72-4중,CA72-4적민감도(SEN)최고(55.1%),CEA적특이도(SPE)최고(78.5%),CA72-4적약등지수(YI)최고(24.3%),CEA적양성예측치(+PV )최고(79.7%)。경평행시험후,CA19-9+CEA+CA72-4적SEN승고도80.9%,서렬시험후,CA19-9+CEA+CA72-4적SPE승고도93.8%。Ⅲ기조、Ⅳ기조혈청CA19-9、CEA、CA72-4농도균명현고우Ⅰ기조、Ⅱ기조농도,기농도적고저여직장암적림상분기존재상관성。결론 CA19-9、CEA、CA72-4가용우보조진단직장암급예측림상분기。
Objective To explore the clinical application of tumor marks with Rectal Cancer .Methods 136 patients with rectal cancer were divided into Ⅰ stage group ,Ⅱ stage group ,Ⅲ stage group ,Ⅳ stage group according to clinical stage ,65 people of intestinal benign lesions as control group .For each group three kinds of serum tumor markers :carbohydrate antigen 19-9 (CA19-9) ,carcino embryonic antigen (CEA ) and carbohydrate antigen 72-4 (CA72-4) levels and associated values .Results The levels of CA19-9 , CEA and CA72-4 in rectal cancer group were (49 .87 ± 16 .33) IU/mL ,(14 .37 ± 15 .12)μg/L and (21 .27 ± 18 .11) IU/mL ,SEN is highest in CA72-4 ,at 55 .1% ;the highest SPE is CEA ,CA72-4 has highest YI , T HE+ PV is highest in CEA .In parallel detection , the SEN of CA19-9 + CEA + CA72-4 went up to 80 .9% and in sequence detection ,the SPE of CA19-9+CEA+CA72-4 went up to 93 .8% .The concentra-tion of CA19-9 ,CEA ,CA72-4 in Ⅲ stage and Ⅳ stage were higher than these in Ⅰ stage and Ⅱ stage ,so the clinic stage was related to the concentration of tumor marks .Conclusion CA19-9 ,CEA ,CA72-4 may-be could assist to diagnose rectal cancer and predict clinic stage .