中外医学研究
中外醫學研究
중외의학연구
CHINESE AND FOREIGN MEDICAL RESEARCH
2014年
14期
13-14
,共2页
腺性膀胱炎%细胞因子%IL-2%IFN-γ%TNF-α
腺性膀胱炎%細胞因子%IL-2%IFN-γ%TNF-α
선성방광염%세포인자%IL-2%IFN-γ%TNF-α
Cystitis glandularis%Cytokine%Interleukin-2%Interferon-γ%Tumor necrosis factor-α
目的：探讨细胞因子IL-2、IFN-γ、TNF-α在腺性膀胱炎发生中的作用。方法：选取笔者所在医院收治的通过膀胱镜检查及活组织病理检查证实为腺性膀胱炎的30例患者设为试验组，另选同期健康体检者30例设为对照组，通过检测两组患者血清中IL-2、IFN-γ、TNF-α细胞因子的表达水平，以及腺性膀胱炎患者治疗3个月后血清中IL-2、IFN-γ、TNF-α细胞因子的表达水平，做出统计分析。结果：试验组有效28例，无效2例，有效率93.3%。治疗前后试验组血清中细胞因子IL-2、IFN-γ、TNF-α均明显高于对照组，差异有统计学意义(P<0.05)。但试验组治疗前后血清中细胞因子IL-2、IFN-γ、TNF-α比较差异无统计学意义(P>0.05)。结论：细胞因子在腺性膀胱炎的发生中起着重要作用；电切加化疗药物膀胱灌注治疗腺性膀胱炎的方法并不能改变患者血清中细胞因子IL-2、IFN-γ、TNF-α水平，患者需要长期随访。
目的：探討細胞因子IL-2、IFN-γ、TNF-α在腺性膀胱炎髮生中的作用。方法：選取筆者所在醫院收治的通過膀胱鏡檢查及活組織病理檢查證實為腺性膀胱炎的30例患者設為試驗組，另選同期健康體檢者30例設為對照組，通過檢測兩組患者血清中IL-2、IFN-γ、TNF-α細胞因子的錶達水平，以及腺性膀胱炎患者治療3箇月後血清中IL-2、IFN-γ、TNF-α細胞因子的錶達水平，做齣統計分析。結果：試驗組有效28例，無效2例，有效率93.3%。治療前後試驗組血清中細胞因子IL-2、IFN-γ、TNF-α均明顯高于對照組，差異有統計學意義(P<0.05)。但試驗組治療前後血清中細胞因子IL-2、IFN-γ、TNF-α比較差異無統計學意義(P>0.05)。結論：細胞因子在腺性膀胱炎的髮生中起著重要作用；電切加化療藥物膀胱灌註治療腺性膀胱炎的方法併不能改變患者血清中細胞因子IL-2、IFN-γ、TNF-α水平，患者需要長期隨訪。
목적：탐토세포인자IL-2、IFN-γ、TNF-α재선성방광염발생중적작용。방법：선취필자소재의원수치적통과방광경검사급활조직병리검사증실위선성방광염적30례환자설위시험조，령선동기건강체검자30례설위대조조，통과검측량조환자혈청중IL-2、IFN-γ、TNF-α세포인자적표체수평，이급선성방광염환자치료3개월후혈청중IL-2、IFN-γ、TNF-α세포인자적표체수평，주출통계분석。결과：시험조유효28례，무효2례，유효솔93.3%。치료전후시험조혈청중세포인자IL-2、IFN-γ、TNF-α균명현고우대조조，차이유통계학의의(P<0.05)。단시험조치료전후혈청중세포인자IL-2、IFN-γ、TNF-α비교차이무통계학의의(P>0.05)。결론：세포인자재선성방광염적발생중기착중요작용；전절가화료약물방광관주치료선성방광염적방법병불능개변환자혈청중세포인자IL-2、IFN-γ、TNF-α수평，환자수요장기수방。
Objective:To investigate the role of the cytokines IL-2,IFN-γ,TNF-αin cystitis glandularis occurred. Method:Selected the author’s hospital treated by cystoscopy and biopsy was confirmed pathologically as cystitis gland sex as experimental group of 30 cases,alternate period health check-up 30 cases as control group,through the detection of the expression levels of two groups of patients with serum IL-2,IFN-γ,TNF-αcytokine,and expression level in the patients with cystitis glandularis after 3 months of treatment the serum levels of IL-2,IFN-γ,TNF-αcytokine,make statistical analysis. Result:Treatment group 28 cases effective,2 cases had no effect,the effective rate was 93.3%. Patients serum cytokine IL-2,IFN-gamma,TNF alpha were significantly higher than that of control group,the difference was statistically significant (P<0.05). But the experimental group before and after treatment serum cytokine IL-2,IFN-gamma,TNF alpha comparison difference had no statistical significance (P>0.05).Conclusion:Cytokines in the gland sex cystitis plays an important role;cutting and bladder perfusion chemotherapy drugs in treatment of glandular cystitis method does not change cytokines in serum IL-2,IFN-γ, TNF-αlevel,patients need long-term follow-up.
