CAJ | 학술논문

作者基于中医临床文献数据，从临床治疗心绞痛血瘀证的方剂出发，使用复杂网络算法构建了中药网络，计算了中药的点中心度（degree）、中间中心度（betweenness centrality）和接近中心度（closeness centrality），以及使用凝聚子图CONCOR迭代相关收敛法分析了中药的聚类情况。结果发现丹参、川芎、黄芪、红花、赤芍的点中心度、中间中心度和接近中心度都较高，为治疗心绞痛血瘀证的核心药物。聚类结果显示，中药可聚类为27个子群，其中4个子群（中药组合）在中药新药处方筛选上有一定的应用价值。为了分析处方内部中药可能的配伍关系，作者对子群进行了二级凝聚子群分析，进一步计算了二级子群的密度，并结合中医理论给出了解释。结论：复杂网络算法可以有效辅助治疗心绞痛血瘀证中药组方的研究。
작자기우중의림상문헌수거，종림상치료심교통혈어증적방제출발，사용복잡망락산법구건료중약망락，계산료중약적점중심도（degree）、중간중심도（betweenness centrality）화접근중심도（closeness centrality），이급사용응취자도CONCOR질대상관수렴법분석료중약적취류정황。결과발현단삼、천궁、황기、홍화、적작적점중심도、중간중심도화접근중심도도교고，위치료심교통혈어증적핵심약물。취류결과현시，중약가취류위27개자군，기중4개자군（중약조합）재중약신약처방사선상유일정적응용개치。위료분석처방내부중약가능적배오관계，작자대자군진행료이급응취자군분석，진일보계산료이급자군적밀도，병결합중의이론급출료해석。결론：복잡망락산법가이유효보조치료심교통혈어증중약조방적연구。
Based on clinical data of TCM formula for treating angina blood stasis syndrome , a Chinese herbal network for treatment of angina blood stasis syndrome was built up by using scale-free network, degree centrality, betweenness centrality and closeness centrality of Chinese herbs were calculated , and subgroup analysis was performed by using CONCOR method .It was found that salvia miltiorrhiza , rhizoma ligustici wallichii , astragalus root , safflower and radix Notoginseng exhibit high centrality , indicating they were crucial compo-nent of the formula to treat of angina blood stasis syndrome .Twenty seven subgroups were discovered , four subgroups are valuable for new TCM formula design .In order to analyze potential compatibility of Chinese herbs , CONCOR analysis was performed on subgroups to obtain network density , and provided explanations from Chinese medicine theory .Conclusion:Scale-free network calculation is a useful method to design TCM formula for treating angina blood stasis syndrome .