CAJ | 학술논문

目的：观察不同方法对腓肠肌急性钝挫伤组织修复的影响，为肌肉损伤的临床治疗提供理论依据。方法：采用定量负荷自由落体打击法复制骨骼肌急性钝挫伤模型。造模成功后将大鼠随机分为6组，即刻予以不同方法干预，观测各组大鼠小腿周径变化；IL-1、IL-8、TNF含量变化；电镜观察肌原纤维损伤情况。结果：电镜下针刺组改变显著，可见肌原纤维损伤部位聚集较多线粒体和肌质网，正常的肌节附近有普遍增多的线粒体，同样范围内肌卫星细胞较其他组多3～4倍；IL-1、TNF水平明显增高的是正红花油组，其次是针刺组和冰敷组，2组间无显著差异；IL-8水平明显增高的是正红花组、针刺组、模型组。结论：骨骼肌损伤后需要良性修复，在临床治疗中，不要一味的消肿、消炎，应考虑如何用药，使肌肉损伤处良性修复，非瘢痕修复，促进肌肉的再生，功能的恢复。
목적：관찰불동방법대비장기급성둔좌상조직수복적영향，위기육손상적림상치료제공이론의거。방법：채용정량부하자유락체타격법복제골격기급성둔좌상모형。조모성공후장대서수궤분위6조，즉각여이불동방법간예，관측각조대서소퇴주경변화；IL-1、IL-8、TNF함량변화；전경관찰기원섬유손상정황。결과：전경하침자조개변현저，가견기원섬유손상부위취집교다선립체화기질망，정상적기절부근유보편증다적선립체，동양범위내기위성세포교기타조다3～4배；IL-1、TNF수평명현증고적시정홍화유조，기차시침자조화빙부조，2조간무현저차이；IL-8수평명현증고적시정홍화조、침자조、모형조。결론：골격기손상후수요량성수복，재림상치료중，불요일미적소종、소염，응고필여하용약，사기육손상처량성수복，비반흔수복，촉진기육적재생，공능적회복。
Objective:To compare the different emergency treatment to acute closed skeletal gastrocnemius muscle injury of rats , and provides theoretical basis to clinical therapeutics on muscle injury .Methods:Modeling gastrocnemius muscle in rats'hindquarter by u-sing method of free falling with quantitative load to simulate acute skeletal muscle injury .Rats are divided into 6 groups and intervened in acute stage with different methods .After acute stage , we took out gastrocnemius of affected side to measure calf circumference , ob-served under electron microscope , and performed ELISA analysis .Results:Significant change was seen in the acupuncture group under electron microscopic observation , around myofibrillar injury site there were more mitochondria and sarcoplasmic reticulum , and more mi-tochondria around normal sarcomere .There was three to four times more muscle satellite cells in the same range than were in other groups .Using Zhenghonghua oil can cause IL-1&TNF level to increase most significantly .The acupuncture&ice groups had IL-1&TNF level increased without significant difference .IL-8 level increased in Zhenghonghua oil , acupuncture and model groups .Conclusion:The skeletal muscle injury need benign repair .Clinical treatment should not focus only on anti-swelling or anti-inflammation medica-tions, but also medication that work to make muscle injury repair benignly and scarlessly , promoting muscle regeneration and functional recovery .