CAJ | 학술논문

[目的]通过对1例人感染H7 N9禽流感病毒患者的调查分析，为人感染H7 N9禽流感的科学防控提供依据。[方法]采用流行病学调查方法，调查病例的发病经过、可能的感染来源、传播途径及暴露因素等，医学观察患者的密切接触者，同时对患者进行临床诊治、实验室检测。[结果]确诊1例人感染H7 N9禽流感病毒，经救治后痊愈出院。患者有明确的活禽接触史，咽拭子检测H7 N9禽流感病毒核酸阳性。患者的密切接触者中均未发现异常临床表现。通过扩大监测流感病例160例和职业人群858例，均未发现H7N9禽流感病毒核酸阳性。当地活禽交易市场鸡咽拭子标本检出2份H7 N9禽流感病毒核酸阳性，阳性鸡来源于外省。[结论]活禽暴露是人感染H7 N9禽流感病毒的关键风险因素，暂无证据人传人，未发现人群隐性感染和轻症病例。仍需开展扩大监测和流行病学调查，以完善对感染谱的认识。
[목적]통과대1례인감염H7 N9금류감병독환자적조사분석，위인감염H7 N9금류감적과학방공제공의거。[방법]채용류행병학조사방법，조사병례적발병경과、가능적감염래원、전파도경급폭로인소등，의학관찰환자적밀절접촉자，동시대환자진행림상진치、실험실검측。[결과]학진1례인감염H7 N9금류감병독，경구치후전유출원。환자유명학적활금접촉사，인식자검측H7 N9금류감병독핵산양성。환자적밀절접촉자중균미발현이상림상표현。통과확대감측류감병례160례화직업인군858례，균미발현H7N9금류감병독핵산양성。당지활금교역시장계인식자표본검출2빈H7 N9금류감병독핵산양성，양성계래원우외성。[결론]활금폭로시인감염H7 N9금류감병독적관건풍험인소，잠무증거인전인，미발현인군은성감염화경증병례。잉수개전확대감측화류행병학조사，이완선대감염보적인식。
[Objective] To investigate and analyze the first case of human infection with highly pathogenic avian influenza virus ( H7N9) so as to provide scientific basis for control of avian influenza infec-tion in humans. [Methods] Epidemiological survey was carried out including the process of morbidity , possible infection source , transmission route and risk factors , etc.Strict observation was made on close con-tacts of the patient .Meanwhile the patient underwent clinical diagnosis , treatment and laboratory tests . [ Results] The patient was confirmed to be infected with highly pathogenic human avian influenza H 7N9 virus as ascertained by expert group of ministry of health ,and was cured and discharged .The patient had definate contact with live poultry , and using H7N9 pharyngeal swab through laboratory tests , avian influenza virus nucleic acid showed positivity results .No abnormalities were found in clinical manifestations in close contacts of the patient.By expanding surveillance on 160 cases of influenza-likeillness(ILI)and 858 cases of professional groups , the samples were not found to be H 7 N9 positive .However , on local live poultry market, two chicken pharyngeal swab specimens were detected to be H 7N9 positive.Positive chickens were from other provinces . [ Conclusion] History of live poultry exposure is believed to be the key risk fac-tors in infection with H7N9 virus.So far there has been no evidence of human-to-human transmission . There has not been subclinical infection or mild cases found in crowd .However ,there is the need to expand monitoring and epidemiological investigation so as to improve the understanding of the disease .