国际检验医学杂志
國際檢驗醫學雜誌
국제검험의학잡지
INTERNATIONAL JOURNAL OF LABORATORY MEDICINE
2014年
8期
979-980
,共2页
冠心病%同型半胱氨酸%高同型半胱氨酸血症%叶酸%维生素B12
冠心病%同型半胱氨痠%高同型半胱氨痠血癥%葉痠%維生素B12
관심병%동형반광안산%고동형반광안산혈증%협산%유생소B12
coronary heart disease%homocysteine%hyperhomocysteinemia%folic acid%vitamin B12
目的：探讨同型半胱氨酸（Hcy）在冠心病（CHD）患者中的诊断价值。方法选择102例CHD患者[急性心肌梗死（AMI）15例，不稳定性心绞痛（UAP）56例，稳定性心绞痛（SAP）31例]为CHD组，100例健康成人为对照组，分别用循环酶法测定血清Hcy水平，用微粒子化学发光免疫分析法测定叶酸（FA）和维生素B12（VB12）水平。结果 AMI组、UAP组和SAP组的Hcy水平，分别为（24．12±5．87）μmol/L、（22．56±6．13）μmol/L、（17．42±5．23）μmol/L ，均明显高于对照组（P＜0．01）。CHD患者和对照组中 Hcy水平均为男性高于女性，高龄组高于低龄组，吸烟组高于非吸烟组，差异均有统计学意义（P＜0．01）。 Hcy水平与FA和VB12水平均呈负相关，相关系数（r）分别为-0．62和-0．47（P＜0．01）。结论高 Hcy血症与CHD发病关系密切， Hcy可作为CHD病变的预警指标。对男性、吸烟和高龄CHD患者，应定期检测Hcy。
目的：探討同型半胱氨痠（Hcy）在冠心病（CHD）患者中的診斷價值。方法選擇102例CHD患者[急性心肌梗死（AMI）15例，不穩定性心絞痛（UAP）56例，穩定性心絞痛（SAP）31例]為CHD組，100例健康成人為對照組，分彆用循環酶法測定血清Hcy水平，用微粒子化學髮光免疫分析法測定葉痠（FA）和維生素B12（VB12）水平。結果 AMI組、UAP組和SAP組的Hcy水平，分彆為（24．12±5．87）μmol/L、（22．56±6．13）μmol/L、（17．42±5．23）μmol/L ，均明顯高于對照組（P＜0．01）。CHD患者和對照組中 Hcy水平均為男性高于女性，高齡組高于低齡組，吸煙組高于非吸煙組，差異均有統計學意義（P＜0．01）。 Hcy水平與FA和VB12水平均呈負相關，相關繫數（r）分彆為-0．62和-0．47（P＜0．01）。結論高 Hcy血癥與CHD髮病關繫密切， Hcy可作為CHD病變的預警指標。對男性、吸煙和高齡CHD患者，應定期檢測Hcy。
목적：탐토동형반광안산（Hcy）재관심병（CHD）환자중적진단개치。방법선택102례CHD환자[급성심기경사（AMI）15례，불은정성심교통（UAP）56례，은정성심교통（SAP）31례]위CHD조，100례건강성인위대조조，분별용순배매법측정혈청Hcy수평，용미입자화학발광면역분석법측정협산（FA）화유생소B12（VB12）수평。결과 AMI조、UAP조화SAP조적Hcy수평，분별위（24．12±5．87）μmol/L、（22．56±6．13）μmol/L、（17．42±5．23）μmol/L ，균명현고우대조조（P＜0．01）。CHD환자화대조조중 Hcy수평균위남성고우녀성，고령조고우저령조，흡연조고우비흡연조，차이균유통계학의의（P＜0．01）。 Hcy수평여FA화VB12수평균정부상관，상관계수（r）분별위-0．62화-0．47（P＜0．01）。결론고 Hcy혈증여CHD발병관계밀절， Hcy가작위CHD병변적예경지표。대남성、흡연화고령CHD환자，응정기검측Hcy。
Objective To study the diagnostic value of homocysteine (Hcy) in coronary heart disease(CHD) .Methods 102 CHD patients were collected as CHD group [15 cases of acute myocardial infarction (AMI) ,56 cases of unstable angina pectoris (UAP) and 31 cases of table angina pectoris (SAP)] and 100 healthy subjects were collected as control group .The level of Hcy was measured by enzymatic cycling assay and the levels of folic acid (FA) and vitamin B12 (VB12 ) were measured by microparticle chemoluminescence immunoassay .Results The Hcy levels of patients with AMI ,UAP and SAP were significantly higher than con-trol group (P<0 .01) .The levels of AMI group ,UAP group and SAP group were (24 .12 ± 5 .87)μmol/L ,(22 .56 ± 6 .13)μmol/L and (17 .42 ± 5 .23)μmol/L ,respectively .Not only in CHD group ,but also in control group ,the level of Hcy in men was signifi-cantly higher than that in women .Similarly ,the level of Hcy were significantly higher in current smokers compared with non-smok-ers as well as in older group compared with young group .There were significant negative correlations between Hcy and FA (r= -0 .62 ,P<0 .01) and VB12 (r= -0 .47 ,P<0 .01) .Conclusion Hyperhomocysteinemia is significantly associated with CHD .Hcy may be an marker for early warning CHD .
