中医药导报
中醫藥導報
중의약도보
GUIDING JOURNAL OF TCM
2013年
9期
69-70,71
,共3页
护肝茶%酒精%急性肝损伤%小鼠
護肝茶%酒精%急性肝損傷%小鼠
호간다%주정%급성간손상%소서
Liver Protecting Tea%Alcohol%Acute Liver Damage%Mice
目的：研究护肝茶对50%乙醇所致急性肝损伤小鼠模型的影响。方法：50只小鼠随机分为5组，空白组，模型组，护肝茶高、中、低剂量组；护肝茶低、中、高剂量组灌胃给药30 d后，灌胃给予50%乙醇致急性肝损伤模型，观察护肝茶对急性肝损伤小鼠肝组织中还原型号谷胱甘肽（GSH）、甘油三酯（TG）、丙二醛（MDA）含量及肝组织病理的影响。结果：护肝茶高剂量组小鼠肝组织内的GSH含量明显提高，TG含量及肝脏脂肪变性程度明显降低，与模型组比较，差异均有统计学意义（P<0.01）。结论：高剂量的护肝茶对小鼠酒精急性肝损伤具有明显的保护作用。
目的：研究護肝茶對50%乙醇所緻急性肝損傷小鼠模型的影響。方法：50隻小鼠隨機分為5組，空白組，模型組，護肝茶高、中、低劑量組；護肝茶低、中、高劑量組灌胃給藥30 d後，灌胃給予50%乙醇緻急性肝損傷模型，觀察護肝茶對急性肝損傷小鼠肝組織中還原型號穀胱甘肽（GSH）、甘油三酯（TG）、丙二醛（MDA）含量及肝組織病理的影響。結果：護肝茶高劑量組小鼠肝組織內的GSH含量明顯提高，TG含量及肝髒脂肪變性程度明顯降低，與模型組比較，差異均有統計學意義（P<0.01）。結論：高劑量的護肝茶對小鼠酒精急性肝損傷具有明顯的保護作用。
목적：연구호간다대50%을순소치급성간손상소서모형적영향。방법：50지소서수궤분위5조，공백조，모형조，호간다고、중、저제량조；호간다저、중、고제량조관위급약30 d후，관위급여50%을순치급성간손상모형，관찰호간다대급성간손상소서간조직중환원형호곡광감태（GSH）、감유삼지（TG）、병이철（MDA）함량급간조직병리적영향。결과：호간다고제량조소서간조직내적GSH함량명현제고，TG함량급간장지방변성정도명현강저，여모형조비교，차이균유통계학의의（P<0.01）。결론：고제량적호간다대소서주정급성간손상구유명현적보호작용。
Objective: To study the influence of Liver Protecting Tea on the model mouse of acute liver injury by alcohol (50%). Methods: 50 mice were divided into 5 group, blank group, model group, Liver Protecting Tea high dose, medium dose and low dose groups. The mice in Liver Protecting Tea high dose, medium dose and low dose groups were induced alcohol a-cute liver damage by alcohol (50%) after irrigation stomach of Liver Protecting for 30 days. And the GSH, TG, MDA and liv-er tissue pathology were observed. Results: Comparing with the model group, the levels of GSH rose, and the levels of TG and degree of hepatic steatosis reduced significantly, in Liver Protecting Tea high dose group (P<0.01). Conclusion: Liver Pro-tecting Tea could protect the alcohol acute liver damage in mouse.
