中国现代医生
中國現代醫生
중국현대의생
CHINA MODERN DOCTOR
2014年
14期
12-15
,共4页
2型糖尿病%非酒精性脂肪性肝病%危险因素%并发症,慢性%胰岛素抵抗
2型糖尿病%非酒精性脂肪性肝病%危險因素%併髮癥,慢性%胰島素牴抗
2형당뇨병%비주정성지방성간병%위험인소%병발증,만성%이도소저항
Type 2 diabetes%Non-alcoholic fatty liver disease%Risk factors%Complications%Chronic%Insulin resis-tance
目的：研究非肥胖2型糖尿病合并非酒精性脂肪性肝病危险因素及与并发症的相关性。方法选择428例非肥胖2型糖尿病患者，分为非酒精性脂肪性肝病组（NAFLD组）193例和非NAFLD组235例，对比两组生活指标、物理指标、一般资料及慢性并发症发生率，分析2型糖尿病合并NAFLD的危险因素。结果 NAFLD组外周血HbA1C、FINS、C肽、HOMA-IR、TC、TG、LDL-C、ALT、AST、UA水平均显著高于非NAFLD组（P＜0.05），AST/ALT比值显著低于非NAFLD组（P＜0.05）。NAFLD组BMI、腰臀比显著高于非NAFLD组（P＜0.05）。其中HOMA-IR、TG、LDL-C、腰臀比是2型糖尿病合并非酒精性脂肪性肝病的危险因素（P＜0.05）。 NAFLD组糖尿病肾病、高血压、动脉粥样硬化、冠心病、脑血管病变的发生率显著高于非NAFLD组（P＜0.05）。结论胰岛素抵抗、血脂异常及体脂分布不均与非肥胖2型糖尿病患者合并NAFLD有关，合并NAFLD的患者血管病变发生率升高。
目的：研究非肥胖2型糖尿病閤併非酒精性脂肪性肝病危險因素及與併髮癥的相關性。方法選擇428例非肥胖2型糖尿病患者，分為非酒精性脂肪性肝病組（NAFLD組）193例和非NAFLD組235例，對比兩組生活指標、物理指標、一般資料及慢性併髮癥髮生率，分析2型糖尿病閤併NAFLD的危險因素。結果 NAFLD組外週血HbA1C、FINS、C肽、HOMA-IR、TC、TG、LDL-C、ALT、AST、UA水平均顯著高于非NAFLD組（P＜0.05），AST/ALT比值顯著低于非NAFLD組（P＜0.05）。NAFLD組BMI、腰臀比顯著高于非NAFLD組（P＜0.05）。其中HOMA-IR、TG、LDL-C、腰臀比是2型糖尿病閤併非酒精性脂肪性肝病的危險因素（P＜0.05）。 NAFLD組糖尿病腎病、高血壓、動脈粥樣硬化、冠心病、腦血管病變的髮生率顯著高于非NAFLD組（P＜0.05）。結論胰島素牴抗、血脂異常及體脂分佈不均與非肥胖2型糖尿病患者閤併NAFLD有關，閤併NAFLD的患者血管病變髮生率升高。
목적：연구비비반2형당뇨병합병비주정성지방성간병위험인소급여병발증적상관성。방법선택428례비비반2형당뇨병환자，분위비주정성지방성간병조（NAFLD조）193례화비NAFLD조235례，대비량조생활지표、물리지표、일반자료급만성병발증발생솔，분석2형당뇨병합병NAFLD적위험인소。결과 NAFLD조외주혈HbA1C、FINS、C태、HOMA-IR、TC、TG、LDL-C、ALT、AST、UA수평균현저고우비NAFLD조（P＜0.05），AST/ALT비치현저저우비NAFLD조（P＜0.05）。NAFLD조BMI、요둔비현저고우비NAFLD조（P＜0.05）。기중HOMA-IR、TG、LDL-C、요둔비시2형당뇨병합병비주정성지방성간병적위험인소（P＜0.05）。 NAFLD조당뇨병신병、고혈압、동맥죽양경화、관심병、뇌혈관병변적발생솔현저고우비NAFLD조（P＜0.05）。결론이도소저항、혈지이상급체지분포불균여비비반2형당뇨병환자합병NAFLD유관，합병NAFLD적환자혈관병변발생솔승고。
Objective To study the risk factors and complications of non-obese type 2 diabetes mellitus with nonalco-holic fatty liver disease. Methods A total of 428 cases of non-obese type 2 diabetic patients were divided into groups of non-alcoholic fatty liver disease (NAFLD group) of 193 cases and non-NAFLD group of 235 cases, compare living index, physical indicators, general information and chronic complications rate of type 2 diabetes risk factors for NAFLD of two groups. Results NAFLD peripheral blood HbA1C, FINS, C peptide, HOMA-IR, TC, TG, LDL-C, ALT, AST, UA levels were significantly higher than non-NAFLD group (P <0.05), AST/ALT ratio were significantly lower in non-NAFLD group (P<0.05). NAFLD group BMI, waist-hip ratio were significantly higher than non-NAFLD group (P <0.05). Included HOMA-IR, TG, LDL-C, waist-hip ratio were type 2 diabetes mellitus with nonalcoholic fatty liver disease risk factors (P <0.05). NAFLD group diabetic nephropathy,hypertension,atherosclerosis,coronary heart disease, cerebrovascular disease incidence were significantly higher than non-NAFLD group(P <0.05). Conclu-sion Insulin resistance, dyslipidemia and fat maldistribution and non-obese type 2 diabetic patients with NAFLD re-lated chronic complications in patients with NAFLD increased incidence.
