CAJ | 학술논문

目的：观察温肾汤治疗早期糖尿病肾病（DN）的临床疗效。方法：80例早期DN患者在采用糖尿病教育、调节控制饮食、适当运动、药物控制血糖的基础上给予温肾汤，1剂/d，水煎分2次口服。4周为1疗程，连续治疗2个疗程后观察患者尿微量蛋白/肌酐（MA/Cr）、血β2微球蛋白（β2-MG）、尿β2-MG、尿α1微球蛋白（α1-MG）、血肌酐（SCr）、血浆纤维蛋白（FIB）、血脂[总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）]变化情况。结果：治疗后MA/Cr、血β2-MG、尿β2-MG、尿α1-MG、血SCr、血FIB均有减少（P＜0.05），TC、TG、LDL-C、HDL-C明显改善（P＜0.05）。结论：温肾汤能有效延缓早期DN的进展，减少尿蛋白，显著改善血脂。
목적：관찰온신탕치료조기당뇨병신병（DN）적림상료효。방법：80례조기DN환자재채용당뇨병교육、조절공제음식、괄당운동、약물공제혈당적기출상급여온신탕，1제/d，수전분2차구복。4주위1료정，련속치료2개료정후관찰환자뇨미량단백/기항（MA/Cr）、혈β2미구단백（β2-MG）、뇨β2-MG、뇨α1미구단백（α1-MG）、혈기항（SCr）、혈장섬유단백（FIB）、혈지[총담고순（TC）、감유삼지（TG）、고밀도지단백담고순（HDL-C）、저밀도지단백담고순（LDL-C）]변화정황。결과：치료후MA/Cr、혈β2-MG、뇨β2-MG、뇨α1-MG、혈SCr、혈FIB균유감소（P＜0.05），TC、TG、LDL-C、HDL-C명현개선（P＜0.05）。결론：온신탕능유효연완조기DN적진전，감소뇨단백，현저개선혈지。
Objective:To observe clinical effects of WenShenTang in treating early diabetic nephropathy (DN). Method:All 80 patients took WenShenTang on the foundation of diabetes education, diet regulation, proper exercise and blood glucose controlling through drugs, one dose per day, water decocted and taking twice. Four weeks were one course of treatment, and the changes of microalbuminuria/creatinine (MA/Cr), blood β2 microglobulin (β2-MG), urinaryβ2 microglobulin (β2-MG), urinary α1 microglobulin (α1-MG), serum creatinine (SCr), plasma fibrinogen (FIB), total cholesterol (TC), glycerin trilaurate (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) were observed after two consecutive courses of treatment. Result: After treating, MA/Cr, bloodβ2-MG, urinaryβ2-MG, urinaryα1-MG, SCr and FIB were decreased (P<0.05), TC, TG, LDL-C and HDL-C were improved obviously (P<0.05). Conclusion:WenShenTang could effectively delay the development of early DN, reduce proteinuria and remarkably improve blood lipid.