风湿病与关节炎
風濕病與關節炎
풍습병여관절염
Rheumatism and Arthritis
2013年
9期
31-36
,共6页
刘彦博%吴启富%杨玥%陈育尧%何敬铭%接红宇
劉彥博%吳啟富%楊玥%陳育堯%何敬銘%接紅宇
류언박%오계부%양모%진육요%하경명%접홍우
金关片%镇痛%抗炎%大鼠%小鼠
金關片%鎮痛%抗炎%大鼠%小鼠
금관편%진통%항염%대서%소서
jinguan tablets%analgesia%anti-inlfammatory%rat%mouse
目的：观察金关片的镇痛抗炎作用。方法：采用大鼠辐射热刺激实验、小鼠热板法实验、小鼠醋酸扭体实验来观察金关片的镇痛作用，采用小鼠毛细血管通透性实验、小鼠白细胞游走实验、角叉菜胶致小鼠足肿胀实验、小鼠棉球肉芽肿实验、大鼠巴豆性气囊肿实验、大鼠胸膜炎实验观察金关片的抗炎作用，采用小鼠肾上腺质量和维生素C含量测定金关片对肾上腺皮脂功能的影响。结果：金关片高、低剂量组均能提高大鼠辐射热刺激痛阈值，提高小鼠热板法痛阈值，抑制醋酸致小鼠扭体反应，抑制小鼠腹腔毛细血管通透性增高，抑制小鼠白细胞游走，减轻角叉菜胶致小鼠足肿胀的程度，抑制小鼠棉球肉芽肿的形成，抑制大鼠巴豆性气囊肿的形成，减少大鼠胸膜腔中白细胞的数量。金关片组大鼠肾上腺内维生素C含量明显低于空白组（P<0.05或P<0.01）。结论：金关片具有良好的镇痛抗炎作用，且与增强肾上腺皮质功能有关。
目的：觀察金關片的鎮痛抗炎作用。方法：採用大鼠輻射熱刺激實驗、小鼠熱闆法實驗、小鼠醋痠扭體實驗來觀察金關片的鎮痛作用，採用小鼠毛細血管通透性實驗、小鼠白細胞遊走實驗、角扠菜膠緻小鼠足腫脹實驗、小鼠棉毬肉芽腫實驗、大鼠巴豆性氣囊腫實驗、大鼠胸膜炎實驗觀察金關片的抗炎作用，採用小鼠腎上腺質量和維生素C含量測定金關片對腎上腺皮脂功能的影響。結果：金關片高、低劑量組均能提高大鼠輻射熱刺激痛閾值，提高小鼠熱闆法痛閾值，抑製醋痠緻小鼠扭體反應，抑製小鼠腹腔毛細血管通透性增高，抑製小鼠白細胞遊走，減輕角扠菜膠緻小鼠足腫脹的程度，抑製小鼠棉毬肉芽腫的形成，抑製大鼠巴豆性氣囊腫的形成，減少大鼠胸膜腔中白細胞的數量。金關片組大鼠腎上腺內維生素C含量明顯低于空白組（P<0.05或P<0.01）。結論：金關片具有良好的鎮痛抗炎作用，且與增彊腎上腺皮質功能有關。
목적：관찰금관편적진통항염작용。방법：채용대서복사열자격실험、소서열판법실험、소서작산뉴체실험래관찰금관편적진통작용，채용소서모세혈관통투성실험、소서백세포유주실험、각차채효치소서족종창실험、소서면구육아종실험、대서파두성기낭종실험、대서흉막염실험관찰금관편적항염작용，채용소서신상선질량화유생소C함량측정금관편대신상선피지공능적영향。결과：금관편고、저제량조균능제고대서복사열자격통역치，제고소서열판법통역치，억제작산치소서뉴체반응，억제소서복강모세혈관통투성증고，억제소서백세포유주，감경각차채효치소서족종창적정도，억제소서면구육아종적형성，억제대서파두성기낭종적형성，감소대서흉막강중백세포적수량。금관편조대서신상선내유생소C함량명현저우공백조（P<0.05혹P<0.01）。결론：금관편구유량호적진통항염작용，차여증강신상선피질공능유관。
Objective:To study the analgesic and anti-inflammatory effects of jinguan tablets in mice and SD rats.Methods:The analgesic effect of jinguan tablets was observed by rat radiant heat stimulation experiment,mice hot plate test and mice acetic acid writhing Test.Its anti-inlfammatory effect was investigated by mice capillary permeability experiment,mice leukocyte migration experiment,carrageenan-induced mice paw swelling experiment,mice granuloma experiment,rats croton gas cysts experiment and rat pleurisy experiment.Mice adrenal weight and vitamin C content were measured to observe the effects of jinguan tablets on adrenal gland sebum.Results:Jinguan tablets could significantly improve rat radiant heat stimulation pain threshold,increase mouse hot-plate test pain threshold,inhibit acetic acid-induced writhing,peritoneal capillary permeability and leukocyte migration,mitigate the extent of the carrageenan-induced paw swelling,inhibit the formation of granuloma and the formation of croton gas cysts,and reduce the number of white blood cells in the pleural cavity. The adrenal vitamin C content in jinguan tablets group was signiifcantly lower than the control group(P<0.05 or P<0.01).Conclusion:Jinguan tablets had obvious analgesic and anti-inlfammatory effects,and was related to the enhancement of adrenal cortex.
