CAJ | 학술논문

目的研究人附睾蛋白4（ HE4）在肺癌患者血清中的表达及临床意义。方法采用酶联免疫吸附法检测239例肺癌患者和57例肺良性疾病患者血清HE4浓度水平，并比较其差异。结果 HE4在肺鳞癌、腺癌、小细胞癌表达阳性率分别为47．71％、45．63％、51．11％，与良性疾病比较（3．51％），差异均有统计学意义（P＜0．05）。而三种病理类型之间比较，差异无统计学意义（P＞0．05）。 I、II期肺癌和III、IV期肺癌表达HE4，差异有统计学意义（P＜0．05）。结论 HE4可作为肺癌的一种新型肿瘤标志物应用于临床。
목적연구인부고단백4（ HE4）재폐암환자혈청중적표체급림상의의。방법채용매련면역흡부법검측239례폐암환자화57례폐량성질병환자혈청HE4농도수평，병비교기차이。결과 HE4재폐린암、선암、소세포암표체양성솔분별위47．71％、45．63％、51．11％，여량성질병비교（3．51％），차이균유통계학의의（P＜0．05）。이삼충병리류형지간비교，차이무통계학의의（P＞0．05）。 I、II기폐암화III、IV기폐암표체HE4，차이유통계학의의（P＜0．05）。결론 HE4가작위폐암적일충신형종류표지물응용우림상。
Objective To study the expression and the clinical significance of human epididymis protein4(HE4)in lung cancer.Methods We measured serum HE4 levels of 239 lung cancer and 57 lung benign disease cases by using our novel enzyme-linked immunosorbent assay system.And the differences were compared.Results The positive expression rate of HE4 in squamous cell carcinoma,adenocarcinoma,and small cell cancer was 47.71%,45.63%,51.11%,respectively.Compared with the rate of benign disease,these differences were considered to be statistically significant(P<0.05).But the differences between the three pathology types of lung cancer had no significance(P>0.05).And the HE4 expression in phase I and II was significantly different to phase III and IV.(P<0.05).Conclusion HE4 has the potential to be clinically used as a new tumor marker for lung cancer .