CAJ | 학술논문

肺癌已经成为全球范围内癌症死亡的首位死因，其5年生存率很低。肺癌的筛查和早期诊断是改善肺癌生存，降低肺癌死亡率的关键。低剂量螺旋CT是近20年肺癌筛查的热点，随机对照试验研究已经证实其可降低肺癌死亡率。但目前低剂量螺旋CT筛查仍存在一些问题。本文对近年来低剂量螺旋CT能否降低肺癌死亡率的争议、随机对照试验的结果及存在的问题进行综述，并对未来低剂量螺旋CT在肺癌筛查中的应用做一展望。
폐암이경성위전구범위내암증사망적수위사인，기5년생존솔흔저。폐암적사사화조기진단시개선폐암생존，강저폐암사망솔적관건。저제량라선CT시근20년폐암사사적열점，수궤대조시험연구이경증실기가강저폐암사망솔。단목전저제량라선CT사사잉존재일사문제。본문대근년래저제량라선CT능부강저폐암사망솔적쟁의、수궤대조시험적결과급존재적문제진행종술，병대미래저제량라선CT재폐암사사중적응용주일전망。
Lung cancer has become the leading cause of cancer mortality globally, and 5-year survival rate is very poor. Screening and early detection are vital to improve survival and decrease mortality of lung cancer. In recent 20 years, low-dose spiral CT (LDCT) screening has become a research focus in this area. Randomized controlled trials have conifrmed that LDCT can decrease lung cancer mortality. However, there are still some problems of LDCT. In this paper, we summarized the controversy that whether low-dose helical CT screening can reduce lung cancer mortality or not before its effectiveness was been conifrmed, the results and problems in the randomized controlled trials and gave a prospect of low-dose helical CT screening’s future application.