CAJ | 학술논문

微生态药物包括益生物、益生菌及其复方产品合生素。国外大量临床随机对照试验结果已肯定此类药物用于儿童消化道感染、呼吸道感染等各类感染及 H IV母婴传播等疾病状态中的疗效。微生态药物用于普通婴幼儿群体是安全的，但用于免疫缺陷、患有某些基础疾病、处于临床危象的患儿或早产儿应谨慎。这是由于益生菌为活体，对于其潜在风险如传递细菌耐药、肠道菌群易位及其诱生性感染、诱发乳酸酸中毒和对肠道菌群的长期不良影响等，都需要在临床中仔细体察。本文重点回顾近10年来益生菌、合生素预防和治疗儿童感染性疾病的临床进展。
미생태약물포괄익생물、익생균급기복방산품합생소。국외대량림상수궤대조시험결과이긍정차류약물용우인동소화도감염、호흡도감염등각류감염급 H IV모영전파등질병상태중적료효。미생태약물용우보통영유인군체시안전적，단용우면역결함、환유모사기출질병、처우림상위상적환인혹조산인응근신。저시유우익생균위활체，대우기잠재풍험여전체세균내약、장도균군역위급기유생성감염、유발유산산중독화대장도균군적장기불량영향등，도수요재림상중자세체찰。본문중점회고근10년래익생균、합생소예방화치료인동감염성질병적림상진전。
Microecological drugs refer to probiotics ,prebiotics ,or with the combination of both ,synbiotics .A vast number of evidence-based studies have accounted for the use of microecological drugs for the pediatric gastrointestinal ,respiratory and other infectious as well as HIV mother-to-fetus transmission .But for those premature infant ,children with immune deficiency diseases or medical condition in common clinical crisis ,as well as burned with certain underlying diseases , medicine use should be cautious .Because probiotics are live ,for their potential risks ,such as transferring of bacterial resistance ,and induced translocation of intestinal microflora naturally infected induce lactic acidosis and long-term adverse effects on the intestinal flora ,etc .,should be carefully observed in clinical .This article focuses on the evidence of clinical benefits of probiotics and synbiotics toward prevention and treatment of childhood infectious diseases in the last decade .