CAJ | 학술논문

目的探讨遗传性压力易感性周围神经病(HNPP)的临床神经电生理改变.方法对1个HNPP家系的先证者及4例家系患者进行神经传导速度检测,并对先证者进行病理组织学检查.结果先证者正中神经、尺神经、腓肠神经感觉神经传导速度(SCV)均减慢；正中神经、尺神经、腓总神经运动神经传导速度(MCV)均减慢.感觉纤维最易累及的神经为腓肠神经,受损程度以腓肠神经最重.运动神经传导检测结果:运动神经诱发电位潜伏期延长者18条异常率75.0％,所查神经远端MCV异常率87.5％.结论 HNPP患者可伴有大部分神经传导障碍,可靠的神经电生理检查是诊断HNPP的重要依据,在无症状的HNPP患者及其家属也可出现神经传导障碍.在HNPP患者嵌压处神经更易受损.
목적 탐토유전성압력역감성주위신경병(HNPP)적림상신경전생리개변.방법 대1개HNPP가계적선증자급4례가계환자진행신경전도속도검측,병대선증자진행병리조직학검사.결과 선증자정중신경、척신경、비장신경감각신경전도속도(SCV)균감만；정중신경、척신경、비총신경운동신경전도속도(MCV)균감만.감각섬유최역루급적신경위비장신경,수손정도이비장신경최중.운동신경전도검측결과:운동신경유발전위잠복기연장자18조이상솔75.0％,소사신경원단MCV이상솔87.5％.결론 HNPP환자가반유대부분신경전도장애,가고적신경전생리검사시진단HNPP적중요의거,재무증상적HNPP환자급기가속야가출현신경전도장애.재HNPP환자감압처신경경역수손.
Objective To investigate the electrophysiological changes of peripheral nerves in both patients with hereditary neuropathy with liability to pressure palsies(HNPP).Methods The nerve conduction velocities of a family consisting of a proband and 4 members were tested,and the proband was detected by biopsy.Results The proband's median nerve,ulnar nerve,sural sensory nerve conduction velocity (SCV) were decreased.The median nerve,ulnar nerve,common peroneal nerve motor nerve conduction velocity(MCV) of proband were decreased.The sensory fibers of the most frequently involved nerve sural nerve,sural nerve damage to the results:the motor nerve conduction motor nerve evoked potential latency and 18 abnormal rate was 75.0％,the nerve distal to the abnormal rate of MCV was 87.5％.Conclusion Prolongation of distal nerve conduction latencies occurs in essentially all individuals whether symptomatic or asymptomatic.Nerves may be more easily damaged at the site of compression.