CAJ | 학술논문

微小RNA(miRNA)是一类长度为19～25 nt的单链小分子非编码RNA,通过与靶基因mRNA 3'端非翻译区结合引起mRNA的剪切、降解及翻译抑制,参与基因的转录后调控.近年来的研究发现,miRNA的异常表达可参与部分癌基因或抑癌基因的表达调控,影响造血细胞的发育和分化,导致血液肿瘤的发生和发展.不同的miRNA表达谱与特异的遗传学异常及编码基因突变相关,能够为不同类型白血病的生物学研究提供新的依据.文章就近年来miRNA在伴不同细胞及分子遗传学异常的急性髓系白血病及急性淋巴细胞白血病中的研究进展作一综述.
미소RNA(miRNA)시일류장도위19～25 nt적단련소분자비편마RNA,통과여파기인mRNA 3'단비번역구결합인기mRNA적전절、강해급번역억제,삼여기인적전록후조공.근년래적연구발현,miRNA적이상표체가삼여부분암기인혹억암기인적표체조공,영향조혈세포적발육화분화,도치혈액종류적발생화발전.불동적miRNA표체보여특이적유전학이상급편마기인돌변상관,능구위불동류형백혈병적생물학연구제공신적의거.문장취근년래miRNA재반불동세포급분자유전학이상적급성수계백혈병급급성림파세포백혈병중적연구진전작일종술.
microRNA (miRNA) refers to small (19-25 nt) single-stranded noncoding RNA molecules that work as post-transcriptional regulator for gene expression by binding to 3' untranslated regions of target mRNA,thus inducing its digestion,degradation and translational repression.Many studies have confirmed that dysregulation of miRNA expression can cause disruption of the hematopoietic system and contribute to leukemogenesis by regulating the expression of some oncogenes and anti-oncogenes.The unique miRNA expression profiles associated with cytogenetic aberrations and mutational status of protein-coding genes may reveal insight into the biology of these leukemia types.This review discussed the latest studies on miRNA expression in different cytogenetic and molecular subtypes of acute myelocytic leukemia and acute lymphoblastic leukemia.