CAJ | 학술논문

目的：分析分化型甲状腺癌（DTC）患者131 I治疗后，血清抗甲状腺球蛋白抗体（A-TG）升高的影响因素。探讨A-TG是否可以作为D T C复发和转移的随访指标。方法2008年1月至2013年2月间106例D T C患者经手术切除甲状腺后行131 I清甲治疗或转移灶治疗，治疗前和治疗后1个月随访测定血清 A-TG、血清甲状腺球蛋白（TG）、血清促甲状腺素（TSH）；分析A-TG与甲状腺手术范围、手术次数、TSH水平、TG水平及甲状腺癌转移复发状况的关系。结果 A-TG阳性率与手术范围、次数和甲状腺癌转移有关（P＜0．05）。A-TG升高可能预示甲状腺组织或转移灶的存在。结论联合检测A-TG、TG及131 I全身SPECT扫描（131 I-WBS）可以提高DTC复发和转移诊断的敏感性和准确性。
목적：분석분화형갑상선암（DTC）환자131 I치료후，혈청항갑상선구단백항체（A-TG）승고적영향인소。탐토A-TG시부가이작위D T C복발화전이적수방지표。방법2008년1월지2013년2월간106례D T C환자경수술절제갑상선후행131 I청갑치료혹전이조치료，치료전화치료후1개월수방측정혈청 A-TG、혈청갑상선구단백（TG）、혈청촉갑상선소（TSH）；분석A-TG여갑상선수술범위、수술차수、TSH수평、TG수평급갑상선암전이복발상황적관계。결과 A-TG양성솔여수술범위、차수화갑상선암전이유관（P＜0．05）。A-TG승고가능예시갑상선조직혹전이조적존재。결론연합검측A-TG、TG급131 I전신SPECT소묘（131 I-WBS）가이제고DTC복발화전이진단적민감성화준학성。
Objective To analyze influence factors of serum A-TG level after DTC 131 I treatment ,to explore whether A-TG can be used as an indicator of follow-up ,recurrence and metastasis of DTC .Methods From 2008 January to 2013 February ,a total of 106 DTC patients underwent operation excisions of thyroid radioiodine were treated with 131 I .Before and 1 month after treatment , the levels of A-TG ,TG ,THS were measured .The relationship of A-TG and thyroid operation range operation times ,thyroid gland residual volume and time ,the levels of TSH and TG ,thyroid cancer metastasis and recurrence were examined .Results Serum A-TG concentration associated with operation scope ,frequency(P<0 .05) .It was showed that the A-TG concentration was positively correlated with the metastasis of thyroid cancer .Conclusion The serum TG level detection combined with A-TG and 131 I-WBS can improve the diagnostic sensitivity and accuracy of DTC recurrence and metastasis .