CAJ | 학술논문

新生儿化脓性脑膜炎（化脑）是指出生4周内由化脓菌引起的脑膜炎症，幸存者40％～50％可留下失听、失明、癫痫、脑积水、智力和（或）运动障碍等后遗症。由于新生儿化脑的症状往往不典型，加上不规范的应用抗生素，以及少数处于病程早期患儿已有临床表现但是脑脊液还没有明显变化的患者，可能造成脑脊液的改变亦不典型，从而给早期诊断带来一定困难。目前有关预后及脑损害的报道多是颅脑计算机断层扫描（ CT）检查，尽管CT能显示脑膜炎但对微小病变不敏感，且CT的发射方式可造成电离辐射的存在，儿童CT检查更能导致寿命辐射风险度的显著上升。近年来，磁共振成像（ MRI ）特别是弥散加权成像（ DWI）已成为评估早期新生儿脑损伤的重要手段之一。
신생인화농성뇌막염（화뇌）시지출생4주내유화농균인기적뇌막염증，행존자40％～50％가류하실은、실명、전간、뇌적수、지력화（혹）운동장애등후유증。유우신생인화뇌적증상왕왕불전형，가상불규범적응용항생소，이급소수처우병정조기환인이유림상표현단시뇌척액환몰유명현변화적환자，가능조성뇌척액적개변역불전형，종이급조기진단대래일정곤난。목전유관예후급뇌손해적보도다시로뇌계산궤단층소묘（ CT）검사，진관CT능현시뇌막염단대미소병변불민감，차CT적발사방식가조성전리복사적존재，인동CT검사경능도치수명복사풍험도적현저상승。근년래，자공진성상（ MRI ）특별시미산가권성상（ DWI）이성위평고조기신생인뇌손상적중요수단지일。
Neonatal purulent meningitis ( PM) is caused by pyogenic bacteria within 4 weeks after birth , and 40%-50%of survivors will suffer from sequela such as hearing loss , blindness, epilepsy, hydrocephalus, intelligence and (or) movement disorders.The symptoms of neonatal PM are not typical , and antibiotics are not used according to standard .A few neonates at early stage have clinical manifestations but without obvious change in cerebrospinal fluid .All of these factors bring difficulties for early diagnosis of PM .CT is the examination method in most of the reports on prognosis and brain damage at present .Although CT can show meningitis , it is not sensitive to minimal lesion.Meanwhile, emission of CT may cause ionizing radiation .Infants taking CT examination can result in significant rise in radiation risk of life expectancy .In recent years , MRI, especially DWI has become one of the important means for early assessment of neonatal brain injury.