CAJ | 학술논문

研究了辛伐他汀（SMV）在表面活性剂十二烷基苯磺酸钠（SDBS）自组装膜与石墨烯（RGO）复合修饰碳糊电极（SDBS-RGO/CPE）上的电催化氧化和电化学动力学性质。实验结果表明，SDBS-RGO/CPE对SMV电化学氧化具有良好的催化作用。同时用循环伏安法（CV），计时电流法（CA）测定了SMV在SDBS-RGO/CPE上的电极反应动力学参数，用方波伏安法（ SWV）测得SMV氧化峰电流（ Ipa ）与其浓度在6.0×10-5～4.5×10-4mol· L-1范围内呈良好线性关系，检测限（S/N＝3）为5.0×10-6mol· L-1，同时运用该方法对市售辛伐他汀片剂中SMV含量进行了电化学定量测定，测定结果符合定量测定要求。
연구료신벌타정（SMV）재표면활성제십이완기분광산납（SDBS）자조장막여석묵희（RGO）복합수식탄호전겁（SDBS-RGO/CPE）상적전최화양화화전화학동역학성질。실험결과표명，SDBS-RGO/CPE대SMV전화학양화구유량호적최화작용。동시용순배복안법（CV），계시전류법（CA）측정료SMV재SDBS-RGO/CPE상적전겁반응동역학삼수，용방파복안법（ SWV）측득SMV양화봉전류（ Ipa ）여기농도재6.0×10-5～4.5×10-4mol· L-1범위내정량호선성관계，검측한（S/N＝3）위5.0×10-6mol· L-1，동시운용해방법대시수신벌타정편제중SMV함량진행료전화학정량측정，측정결과부합정량측정요구。
Electrocatalytic oxidation and electrochemical kinetics of simvastatin ( SMV) were investigated at sodium dodecyl benzene-sulfonate(SDBS)self-assembled monolayers and graphene (RGO)modified carbon paste electrode(SDBS-RGO/CPE).The experi-mental results showed that SDBS-RGO/CPE showed an excellent electrocatalytic activity towards SMV electrochemical oxida -tion.The electrochemical kinetic parameters were also determined by cyclic voltammetry ( CV) and chronoamperometry ( CA).The oxidation peak current of catalytic oxidation of SMV versus its concentration had a good linear relationship in the concentration range of 6.0 ×10-5 mol· L-1 ~4.5 ×10-4 mol· L-1 and the detection limit of 5.0 ×10-6 mol· L-1 ( S/N=3 ) by square wave voltammetry ( SWV).At the same time the supposed method have been applied in the electrochemical quantitative determination of SMV content in commercial tablet samples and the determination results meet the requirement of the quantitative determination .