CAJ | 학술논문

目的研究轻度认知功能障碍（mild cognitive impairment，MCI）患者认知损害与血清脑源性神经营养因子（brain derived neurotrophic factor，BDNF）水平的关系。方法从认知障碍门诊筛选MCI患者30例，正常对照老年人32例，采用酶联免疫吸附法（enzyme linked immunosorbent assay，ELISA）检测MCI患者的血清BDNF水平。结果 MCI的血清BDNF水平较正常对照组显著升高（P=0.025），MCI组中血清BDNF与简明精神状态量表（Mini-Mental State Examination Scale，MMSE）中的记忆力（r=-0.494，P=0.009）、语言能力（r=-0.399，P=0.039）呈负相关，与定向力、注意力和计算力、回忆能力无相关性；与临床痴呆量表（Clinical Dementia Rating Scale，CDR）总分呈正相关（r=0.476，P=0.012）；与MMSE总分、全面衰退量表（Global Deterioration Scale，GDS）总分无相关性。结论 MCI患者的BDNF水平显著升高，提示BDNF可能参与MCI认知损害的病理生理过程。
목적연구경도인지공능장애（mild cognitive impairment，MCI）환자인지손해여혈청뇌원성신경영양인자（brain derived neurotrophic factor，BDNF）수평적관계。방법종인지장애문진사선MCI환자30례，정상대조노년인32례，채용매련면역흡부법（enzyme linked immunosorbent assay，ELISA）검측MCI환자적혈청BDNF수평。결과 MCI적혈청BDNF수평교정상대조조현저승고（P=0.025），MCI조중혈청BDNF여간명정신상태량표（Mini-Mental State Examination Scale，MMSE）중적기억력（r=-0.494，P=0.009）、어언능력（r=-0.399，P=0.039）정부상관，여정향력、주의력화계산력、회억능력무상관성；여림상치태량표（Clinical Dementia Rating Scale，CDR）총분정정상관（r=0.476，P=0.012）；여MMSE총분、전면쇠퇴량표（Global Deterioration Scale，GDS）총분무상관성。결론 MCI환자적BDNF수평현저승고，제시BDNF가능삼여MCI인지손해적병리생리과정。
Objective To investigate the relationship between cognitive function and brain-derived neurotrophic factor (BDNF) in mild cognitive impairment and healthy elders. Methods From the community society, we selected 30 samples of mild cognitive impairment (MCI) and 32 control samples. The cognitive function was evaluated by neuropsychological test and the level of BDNF was tested by enzyme-linked immunosorbent assay (ELISA). Results Compared to the control group, the level of BDNF in MCI patients was signiifcantly increased than healthy elders (P=0.025). Also, the level of BDNF in MCI patients was negatively correlated to memory (r=-0.494, P=0.009) and language (r=-0.399, P=0.039) of Mini-Mental State Examination Scale, and positively correlated to the scores of Clinical Dementia Rating Scale (r=0.476,P=0.012). Conclusion The increased level of BDNF in MCI patients showed that BDNF may be involved in the pathophysiology of cognitive impairment.