中华老年医学杂志
中華老年醫學雜誌
중화노년의학잡지
Chinese Journal of Geriatrics
2014年
1期
35-38
,共4页
苗丽君%张瑞霞%王静%王焕勤
苗麗君%張瑞霞%王靜%王煥勤
묘려군%장서하%왕정%왕환근
肺疾病,慢性阻塞性%体质量指数
肺疾病,慢性阻塞性%體質量指數
폐질병,만성조새성%체질량지수
Pulmonary disease,chronic obstructive%Body mass index
目的 评价慢性阻塞性肺疾病(COPD)住院患者长期生存率和体质指数(BMI)之间的关系. 方法 采用回顾性队列研究的方法,选取自2007年1月1日至2011年12月31日入住我院的1528例COPD患者中资料完整的1124例为研究对象,患者死亡时间从死亡登记处和民政部门获得,从病历资料中收集患者的临床特点.1124例患者的BMI中位数为22.7 kg/m2,根据BMI的四分位数将患者分为:BMI＜18.9 kg/m2组,BMI 18.9～22.7 kg/m2组,BMI 22.8～26.2 kg/m2组,BMI＞26.2 kg/m2组,采用log-rank检验比较不同组患者的生存率曲线差异,应用Cox比例风险回归模型评价全死因病死率与BMI等因素的关系. 结果 1124例患者中270例(24.0 ％) BMI＜18.5kg/m2,随访期间共有162例(14.4％)患者死亡.不同BMI四分位数患者的生存率曲线差异具有统计学意义(x2 =7.97,P=0.043),其中BMI处于22.8～26.2 kg/m2患者的生存率最高,而BMI＜18.9 kg/m2患者的生存率最低.经Cox多因素回归分析调整其他因素影响后,BMI仍为预测死亡的独立危险因素,与BMI＜18.9 kg/m2的患者比较,BMI为22.8～26.2 kg/m2和BMI＞26.2 kg/m2的患者病死率分别降低了41％和35％. 结论 COPD患者常伴有体质量降低,BMI是预测长期生存率的独立危险因素,且BMI具有容易获得、相对稳定的优点,尤其适合于评估急性加重期COPD患者的预后.
目的 評價慢性阻塞性肺疾病(COPD)住院患者長期生存率和體質指數(BMI)之間的關繫. 方法 採用迴顧性隊列研究的方法,選取自2007年1月1日至2011年12月31日入住我院的1528例COPD患者中資料完整的1124例為研究對象,患者死亡時間從死亡登記處和民政部門穫得,從病歷資料中收集患者的臨床特點.1124例患者的BMI中位數為22.7 kg/m2,根據BMI的四分位數將患者分為:BMI＜18.9 kg/m2組,BMI 18.9～22.7 kg/m2組,BMI 22.8～26.2 kg/m2組,BMI＞26.2 kg/m2組,採用log-rank檢驗比較不同組患者的生存率麯線差異,應用Cox比例風險迴歸模型評價全死因病死率與BMI等因素的關繫. 結果 1124例患者中270例(24.0 ％) BMI＜18.5kg/m2,隨訪期間共有162例(14.4％)患者死亡.不同BMI四分位數患者的生存率麯線差異具有統計學意義(x2 =7.97,P=0.043),其中BMI處于22.8～26.2 kg/m2患者的生存率最高,而BMI＜18.9 kg/m2患者的生存率最低.經Cox多因素迴歸分析調整其他因素影響後,BMI仍為預測死亡的獨立危險因素,與BMI＜18.9 kg/m2的患者比較,BMI為22.8～26.2 kg/m2和BMI＞26.2 kg/m2的患者病死率分彆降低瞭41％和35％. 結論 COPD患者常伴有體質量降低,BMI是預測長期生存率的獨立危險因素,且BMI具有容易穫得、相對穩定的優點,尤其適閤于評估急性加重期COPD患者的預後.
목적 평개만성조새성폐질병(COPD)주원환자장기생존솔화체질지수(BMI)지간적관계. 방법 채용회고성대렬연구적방법,선취자2007년1월1일지2011년12월31일입주아원적1528례COPD환자중자료완정적1124례위연구대상,환자사망시간종사망등기처화민정부문획득,종병력자료중수집환자적림상특점.1124례환자적BMI중위수위22.7 kg/m2,근거BMI적사분위수장환자분위:BMI＜18.9 kg/m2조,BMI 18.9～22.7 kg/m2조,BMI 22.8～26.2 kg/m2조,BMI＞26.2 kg/m2조,채용log-rank검험비교불동조환자적생존솔곡선차이,응용Cox비례풍험회귀모형평개전사인병사솔여BMI등인소적관계. 결과 1124례환자중270례(24.0 ％) BMI＜18.5kg/m2,수방기간공유162례(14.4％)환자사망.불동BMI사분위수환자적생존솔곡선차이구유통계학의의(x2 =7.97,P=0.043),기중BMI처우22.8～26.2 kg/m2환자적생존솔최고,이BMI＜18.9 kg/m2환자적생존솔최저.경Cox다인소회귀분석조정기타인소영향후,BMI잉위예측사망적독립위험인소,여BMI＜18.9 kg/m2적환자비교,BMI위22.8～26.2 kg/m2화BMI＞26.2 kg/m2적환자병사솔분별강저료41％화35％. 결론 COPD환자상반유체질량강저,BMI시예측장기생존솔적독립위험인소,차BMI구유용역획득、상대은정적우점,우기괄합우평고급성가중기COPD환자적예후.
Objective To investigate the relationship between body mass index (BMI) and long-term survival in patients with chronic obstructive pulmonary disease (COPD).Methods A retrospective cohort study was conducted in 1124 patients with completed data among 1528 hospitalized patients with COPD.Vital status was ascertained at death registry and civil affairs department.Clinical characteristics were acquired from medical record.Patients were divided into 4 groups according to the quartile of BMI:BMI＜18.9 kg/m2 (group A),BMI from 18.9 kg/m2to 22.7 kg/m2 (group B),BMI from 22.8 kg/m2 to 26.2 kg/m2 (group C),BMI＞26.2 kg/m2 (group D).The differences in survival curves were compared between groups by using log-rank test.The relationship between all-cause mortality and BMI was evaluated by Cox proportional hazards regression model.Results The median BMI of 1124 patients was 22.7 kg/m2 [(18.9-26.2) kg/m2].270 patients (24.0％) had BMI＜18.5 kg/m2.162 patients (14.4％) died during follow-up.There was significant difference in the survival curves in the four groups (x2 =7.97,P＜0.05).Survival rate was highest in group C and lowest in group A.After adjustment for other factors,BMI was an independent risk factor for predicting long-term survival.The survival rate was respectively decreased by 41 ％ and 35 ％ in group C and D as compared with group A.Conclusions Weight loss is comman in COPD patients.BMI is an independent risk factor for predicting long-term survival.BMI is easily acquired and stable,which is especially suitable to evaluate the prognosis of patients with acute exacerbation.
