CAJ | 학술논문

目的：探讨新生儿胆红素脑病脑脊液胆红素水平及脑干听觉诱发电位（BAEP）检查的临床意义。方法选取高胆红素血症新生儿为研究对象，分为胆红素脑病组（44例）和非胆红素脑病组（79例），比较两组患儿脑脊液、血清胆红素水平以及BAEP变化。结果胆红素脑病组患儿脑脊液胆红素水平高于非胆红素脑病组[（11．0±3．9） mol/L VS （7．4±4．0） mol/L]，差异有统计学意义（P＜0．05）；胆红素脑病组BAEP异常发生率（61．4％）高于非胆红素脑病组（16．5％），差异有统计学意义（P＜0．01）。结论脑脊液胆红素水平检测可作为新生儿胆红素脑病早期诊断的可靠指标，胆红素脑病新生儿早期听觉损伤发生率高，需早期干预治疗。
목적：탐토신생인담홍소뇌병뇌척액담홍소수평급뇌간은각유발전위（BAEP）검사적림상의의。방법선취고담홍소혈증신생인위연구대상，분위담홍소뇌병조（44례）화비담홍소뇌병조（79례），비교량조환인뇌척액、혈청담홍소수평이급BAEP변화。결과담홍소뇌병조환인뇌척액담홍소수평고우비담홍소뇌병조[（11．0±3．9） mol/L VS （7．4±4．0） mol/L]，차이유통계학의의（P＜0．05）；담홍소뇌병조BAEP이상발생솔（61．4％）고우비담홍소뇌병조（16．5％），차이유통계학의의（P＜0．01）。결론뇌척액담홍소수평검측가작위신생인담홍소뇌병조기진단적가고지표，담홍소뇌병신생인조기은각손상발생솔고，수조기간예치료。
Objective To explore the clinical significance of cerebrospinal fluid bilirubin level and brainstem auditory evoked poten -tial in neonatal bilirubin encephalopathy .Methods All the cases with hyperbilirubinemia were selected from July 2011 to July 2013 in our department,and were divided into the bilirubin encephalopathy group (44 cases) and the non-bilirubin encephalopathy group (79 cases).Ce-rebrospinal fluid ,serum bilirubin level and brainstem auditory evoked potential ( BAEP ) changes were compared between the two groups of children .Results The cerebrospinal fluid bilirubin level in bilirubin encephalopathy group was higher than that of non -bilirubin encephalopa-thy group [(11.0 +3.9) tendency/L vs (7.4 +4.0) tendency/L],and the difference was statistically significant (P<0.01).The inci-dence of abnormal BAEP (61.4%) in bilirubin encephalopathy group was higher than that of non-bilirubin encephalopathy group (16.5%), and the difference was statistically significant (P<0.01).Conclusion Cerebrospinal fluid bilirubin can be used as a reliable indicator for bilirubin encephalopathy in the early diagnosis ,and newborn infants with bilirubin encephalopathy accompanied by higher incidence of hearing damage require early intervention treatment .