CAJ | 학술논문

目的：了解碘造影剂不良反应的发生率及其相关因素，探索药品上市后不良反应再评价的方法。方法收集、整理、分析有关碘造影剂的不良反应的临床研究、不良反应监测及案例报道，包括个案和经典案例分析。结果本研究纳入9012例碘造影剂不良反应（ADR）；原发疾病为循环系统的患者、老年患者及有其他药物过敏史的患者更容易发生ADR ；ADR多发生在30 min内；根据发表资料尚无法鉴别ADR。结论当前的证据表明，碘造影剂的ADR高，临床使用应密切关注，防止给患者带来不必要的伤害。
목적：료해전조영제불량반응적발생솔급기상관인소，탐색약품상시후불량반응재평개적방법。방법수집、정리、분석유관전조영제적불량반응적림상연구、불량반응감측급안례보도，포괄개안화경전안례분석。결과본연구납입9012례전조영제불량반응（ADR）；원발질병위순배계통적환자、노년환자급유기타약물과민사적환자경용역발생ADR ；ADR다발생재30 min내；근거발표자료상무법감별ADR。결론당전적증거표명，전조영제적ADR고，림상사용응밀절관주，방지급환자대래불필요적상해。
Objective To find out the occurrence rate of adverse drug reaction (ADR) following iodine-contrast media and to under-stand the relative factors causing ADR ,to preliminarily explore the methods for re-evaluation of the drug after marketing .Method The literature was classified into 3 categorise ,i .e .synchronous clinical study ,ADR monitoring and medical records analysis ,as well as individual or typical case reports .Results Totally 9 012 cases were included in this review .Although we are unable to an-swer the question weather the incidence of adverse drug reaction (ADR) induced by iodine-contrast media due to the absence of to-tal amount of production and market information ,it was estimated based on the limited data that the possibility of ADR should be high .The review showed that the ADR was easier to occur in 30 min after injecting into the older and the one who had circulation system disease or drug allergy .Conclusion Current evidence shows that iodine-contrast media has a high risk of ADR .We should pay close attention to the application of iodine-contrast media to prevent unnecessary harmness .