中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2014年
2期
210-213
,共4页
任青%张勇军%魏丽夏%赵丽丽%赵静
任青%張勇軍%魏麗夏%趙麗麗%趙靜
임청%장용군%위려하%조려려%조정
硬肿症%新生儿%尿绒毛膜酶%肾功能损害
硬腫癥%新生兒%尿絨毛膜酶%腎功能損害
경종증%신생인%뇨융모막매%신공능손해
Sclerema neonatorum%Newborn%Urinary brush border membrane enzyme%Renal injury
目的 探讨新生儿硬肿症(SN)尿绒毛膜酶、血胱抑素C(Cys C)的改变能否作为评价肾功能的指标.方法 2009年6月至2013年3月我院收诊69例硬肿症新生儿作为硬肿症组(轻度39例和中重度30例).利用单克隆抗体,用免疫催化方法检测69例硬肿症组治疗前及30例正常新生儿(对照组)尿绒毛膜酶的浓度,并测定两组尿β2微球蛋白(β2-MG)浓度.同时,检测两组血Cys C、尿素氮(BUN)、肌酐(Cr)浓度.结果 硬肿症组尿绒毛膜酶、β2微球蛋白和血Cys C浓度[(40.09±7.29)U/L,(4.65±1.33) mg/L和(1.84±0.32) mg/L]高于对照组[(23.19±5.62) U/L,(2.49±0.77) mg/L和(1.07±0.25) mg/L](t值分别为10.34,7.47和10.55,P均＜0.01),且中重度硬肿症组尿绒毛膜酶、血Cys C浓度[(42.06±7.59) U/L,(1.93±0.34) mg/L]高于轻度组[(38.57±6.70) U/L,(1.77±0.29) mg/L](t值分别为2.24,2.11,P均＜0.05);硬肿症组尿绒毛膜酶、血Cys C的异常发生率分别为79.7％ (55/69)、72.5％ (50/69),显著高于尿β2微球蛋白52.2％ (36/69)(x2分别为12.95、12.11,P均＜0.01);硬肿症组中,尿绒毛膜酶与β2微球蛋白正相关(r=0.560,P＜0.01);血Cys C与BUN、Cr亦有正相关关系(r =0.314,0.287,P均＜0.05).结论 SN患儿肾功能损害多见,尿绒毛膜酶、血Cys C能灵敏地早期发现SN肾损害.
目的 探討新生兒硬腫癥(SN)尿絨毛膜酶、血胱抑素C(Cys C)的改變能否作為評價腎功能的指標.方法 2009年6月至2013年3月我院收診69例硬腫癥新生兒作為硬腫癥組(輕度39例和中重度30例).利用單剋隆抗體,用免疫催化方法檢測69例硬腫癥組治療前及30例正常新生兒(對照組)尿絨毛膜酶的濃度,併測定兩組尿β2微毬蛋白(β2-MG)濃度.同時,檢測兩組血Cys C、尿素氮(BUN)、肌酐(Cr)濃度.結果 硬腫癥組尿絨毛膜酶、β2微毬蛋白和血Cys C濃度[(40.09±7.29)U/L,(4.65±1.33) mg/L和(1.84±0.32) mg/L]高于對照組[(23.19±5.62) U/L,(2.49±0.77) mg/L和(1.07±0.25) mg/L](t值分彆為10.34,7.47和10.55,P均＜0.01),且中重度硬腫癥組尿絨毛膜酶、血Cys C濃度[(42.06±7.59) U/L,(1.93±0.34) mg/L]高于輕度組[(38.57±6.70) U/L,(1.77±0.29) mg/L](t值分彆為2.24,2.11,P均＜0.05);硬腫癥組尿絨毛膜酶、血Cys C的異常髮生率分彆為79.7％ (55/69)、72.5％ (50/69),顯著高于尿β2微毬蛋白52.2％ (36/69)(x2分彆為12.95、12.11,P均＜0.01);硬腫癥組中,尿絨毛膜酶與β2微毬蛋白正相關(r=0.560,P＜0.01);血Cys C與BUN、Cr亦有正相關關繫(r =0.314,0.287,P均＜0.05).結論 SN患兒腎功能損害多見,尿絨毛膜酶、血Cys C能靈敏地早期髮現SN腎損害.
목적 탐토신생인경종증(SN)뇨융모막매、혈광억소C(Cys C)적개변능부작위평개신공능적지표.방법 2009년6월지2013년3월아원수진69례경종증신생인작위경종증조(경도39례화중중도30례).이용단극륭항체,용면역최화방법검측69례경종증조치료전급30례정상신생인(대조조)뇨융모막매적농도,병측정량조뇨β2미구단백(β2-MG)농도.동시,검측량조혈Cys C、뇨소담(BUN)、기항(Cr)농도.결과 경종증조뇨융모막매、β2미구단백화혈Cys C농도[(40.09±7.29)U/L,(4.65±1.33) mg/L화(1.84±0.32) mg/L]고우대조조[(23.19±5.62) U/L,(2.49±0.77) mg/L화(1.07±0.25) mg/L](t치분별위10.34,7.47화10.55,P균＜0.01),차중중도경종증조뇨융모막매、혈Cys C농도[(42.06±7.59) U/L,(1.93±0.34) mg/L]고우경도조[(38.57±6.70) U/L,(1.77±0.29) mg/L](t치분별위2.24,2.11,P균＜0.05);경종증조뇨융모막매、혈Cys C적이상발생솔분별위79.7％ (55/69)、72.5％ (50/69),현저고우뇨β2미구단백52.2％ (36/69)(x2분별위12.95、12.11,P균＜0.01);경종증조중,뇨융모막매여β2미구단백정상관(r=0.560,P＜0.01);혈Cys C여BUN、Cr역유정상관관계(r =0.314,0.287,P균＜0.05).결론 SN환인신공능손해다견,뇨융모막매、혈Cys C능령민지조기발현SN신손해.
Objective To investigate the changes of urinary brush border membrane enzymes and serum cystatin C (Cys C) in newborns in order to develop early diagnostic indicators for sclerema neonatorum (SN) renal dysfunction.Methods Sixty-night cases with sclerema neonatorum and 30 cases of normal newborns were enrolled in this study.Of all sclerema neonatorum cases,39 cases were mild and 30 cases were moderate to severe sclerema neonatorum.Immunoca talytic assay method was adapted to detect the level of urinary brush border membrane.The levels of serum Cys C,blood urea nitrogen (BUN),creatinine (Cr) and urinary β32 microglobulin (β2-MG) in two groups were also measured.Results The levels of urinary brush border membrane enzyme,β2-MG and serum Cys C in sclerema neonatorum group were (40.09 ± 7.29) U/L,(4.65 ± 1.33) mg/L and (1.84 ± 0.32) mg/L,higher than those in control group ((23.19 ± 5.62) U/L,(2.49 ± 0.77) mg/L and (1.07 ± 0.25) mg/L; t =10.34,7.47 and 10.55,P ＜ 0.01).The levels of urinary brush border membrane enzyme and serum Cys C in moderate to severe sclerema neonatorum group were (42.06 ± 7.59) U/L and (1.93 ± 0.34) mg/L,higher than those in the mild group ((38.57 ± 6.70) U/L,(1.77 s0.29) mg/L;t =2.24,2.11,P ＜0.05).The abnormality rates of urinary brush border membrane enzyme and serum Cys C in sclerema neonatorum group were 79.7％ (55/69) and 72.5％ (50/69),higher than β2-MG abnormal rate (52.2％ (36/69),x2 =12.95,12.11,P ＜ 0.01).In sclerema neonatorum group,urinary brush border membrane enzyme was positively correlated with β2-MG (r =0.560,P ＜ 0.01),and serum Cys C was positively correlated with BUN,Cr (r =0.314,0.287,P ＜ 0.05).Conclusion Renal injury is common in SN.Urinary brush border membrane enzyme and serum Cys C are served as the diagnostic parameters for early detection of renal injury in SN.
